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HomoloGene:496. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TNF,  H.sapiens
tumor necrosis factor
    NP_000585.2
233 aa
   TNF,  P.troglodytes
tumor necrosis factor
    NP_001038976.1
232 aa
   TNF,  M.mulatta
tumor necrosis factor
    NP_001040614.1
233 aa
   TNF,  C.lupus
tumor necrosis factor
    NP_001003244.4
233 aa
   TNF,  B.taurus
tumor necrosis factor
    NP_776391.2
234 aa
   Tnf,  M.musculus
tumor necrosis factor
    NP_038721.1
235 aa
   Tnf,  R.norvegicus
tumor necrosis factor
    NP_036807.1
235 aa
   tnf,  X.tropicalis
tumor necrosis factor
    NP_001107143.1
227 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Migraine without aura, susceptibility to.
Dementia, vascular, susceptibility to.
Septic shock, susceptibility to.
Malaria, cerebral, susceptibility to.
Asthma, susceptibility to.
Malaria, cerebral, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

TNF-α 308 G/A polymorphism and cervical intraepithelial neoplasia.
Rotar IC, et al. Anticancer Res 34, 373-8 (2014).
Superoxide release from contracting skeletal muscle in pulmonary TNF-α overexpression mice.
Zuo L, et al. Am J Physiol Regul Integr Comp Physiol 306, R75-81 (2014).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TNF (cl00147)
  Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tnf includes H.sapiens TNF and R.norvegicus Tnf.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 15 species)

 

 

 

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