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HomoloGene:20545. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MMP3,  H.sapiens
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
    NP_002413.1
477 aa
   MMP3,  P.troglodytes
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
    XP_508723.2
477 aa
   MMP3,  M.mulatta
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
    XP_001098400.1
477 aa
   MMP3,  C.lupus
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
    NP_001002967.1
478 aa
   MMP3,  B.taurus
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
    NP_001193566.1
477 aa
   Mmp3,  M.musculus
matrix metallopeptidase 3
    NP_034939.1
479 aa
   Mmp3,  R.norvegicus
matrix metallopeptidase 3
    NP_598207.2
475 aa
   LOC428086,  G.gallus
stromelysin-1-like
    XP_425644.4
477 aa
   LOC100491214,  X.tropicalis
matrix metalloproteinase-18-like
    XP_002934976.2
455 aa
   mmp1,  X.tropicalis
matrix metallopeptidase 1 (interstitial collagenase)
    NP_001025501.1
467 aa
   LOC100489571,  X.tropicalis
matrix metalloproteinase-18-like
    XP_002934968.1
466 aa
   LOC100489735,  X.tropicalis
matrix metalloproteinase-18-like
    XP_002934969.2
459 aa
   LOC100491547,  X.tropicalis
matrix metalloproteinase-18-like
    XP_002934977.2
378 aa
   LOC100494588,  X.tropicalis
matrix metalloproteinase-18-like
    XP_002944454.2
455 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Coronary heart disease, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

[Association of matrix metalloproteinase-3 gene polymorphisms with subtypes of ischemic stroke].
Ma AJ, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30, 461-6 (2013).
Association of MMP3-1171(5A>6A) polymorphism with lung cancer in Lebanon.
Fakhoury HM, et al. Genet Test Mol Biomarkers 16, 988-90 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PG_binding_1 (pfam01471)
  Putative peptidoglycan binding domain.
HX (cd00094)
  Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
PG_binding_1 (pfam01471)
  Putative peptidoglycan binding domain.
ZnMc (cl00064)
  Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mmp3 includes H.sapiens MMP3 and R.norvegicus Mmp3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 7 species)

Apicomplexa
Coccidia - apicomplexans (2 transcripts, 1 species)

 

 

 

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