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HomoloGene:9478. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PLCE1,  H.sapiens
phospholipase C, epsilon 1
    NP_057425.3
2302 aa
   PLCE1,  P.troglodytes
phospholipase C, epsilon 1
    XP_001149565.1
2301 aa
   PLCE1,  M.mulatta
phospholipase C, epsilon 1
    XP_002805823.1
2180 aa
   PLCE1,  C.lupus
phospholipase C, epsilon 1
    NP_001130037.1
2309 aa
   PLCE1,  B.taurus
phospholipase C, epsilon 1
    NP_001192781.1
2297 aa
   Plce1,  M.musculus
phospholipase C, epsilon 1
    NP_062534.2
2282 aa
   Plce1,  R.norvegicus
phospholipase C, epsilon 1
    NP_446210.1
2281 aa
   LOC425224,  G.gallus
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1-like
    XP_004942210.1
2316 aa
   plce1,  X.tropicalis
phospholipase C, epsilon 1
    XP_002937222.2
1777 aa
   plce1,  D.rerio
phospholipase C, epsilon 1
    NP_001155125.1
2248 aa
   plc-1,  C.elegans
plc-1
    NP_001123141.1
1875 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Nephrotic syndrome, type 3.



Publications
Articles associated with genes and sequences of this homology group.

PLCE1 rs2274223 A>G polymorphism and cancer risk: a meta-analysis.
Umar M, et al. Tumour Biol 34, 3537-44 (2013).
Activity of PLCε contributes to chemotaxis of fibroblasts towards PDGF.
Martins M, et al. J Cell Sci 125, 5758-69 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
RasGEF (pfam00617)
  RasGEF domain.
UBQ (cl00155)
  Ubiquitin-like proteins.
RasGEF (cl02485)
  Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
PI-PLCc_GDPD_SF (cl14615)
  Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily.
UBQ (cl00155)
  Ubiquitin-like proteins.
RasGEF (cl02485)
  Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
EF-hand_like (cl08538)
  Phosphoinositide-specific phospholipase C, efhand-like.
C2 (cl14603)
  C2 domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Plce1 includes H.sapiens PLCE1 and R.norvegicus Plce1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 8 species)
Actinopterygii - bony fishes (6 transcripts, 4 species)
Aves - birds (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)
Arachnida - arachnids (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

 

 

 

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