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HomoloGene:20712. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TYK2,  H.sapiens
tyrosine kinase 2
    NP_003322.3
1187 aa
   TYK2,  P.troglodytes
tyrosine kinase 2
    XP_001165313.2
1131 aa
   TYK2,  M.mulatta
tyrosine kinase 2
    XP_001101130.2
1097 aa
   TYK2,  C.lupus
tyrosine kinase 2
    XP_005633269.1
1189 aa
   TYK2,  B.taurus
tyrosine kinase 2
    NP_001107236.1
1185 aa
   Tyk2,  M.musculus
tyrosine kinase 2
    NP_001192241.1
1207 aa
   Tyk2,  R.norvegicus
tyrosine kinase 2
    NP_001244276.1
1186 aa
   tyk2,  X.tropicalis
tyrosine kinase 2
    XP_004918872.1
1178 aa
   tyk2,  D.rerio
tyrosine kinase 2
    XP_003198201.2
1165 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Protein-tyrosine kinase 2 deficiency.



Publications
Articles associated with genes and sequences of this homology group.

The role of Tyk2 in regulation of breast cancer growth.
Zhang Q, et al. J Interferon Cytokine Res 31, 671-7 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
B41 (smart00295)
  Band 4.1 homologues.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
PH-like (cl17171)
  Pleckstrin homology-like domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tyk2 includes H.sapiens TYK2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 11 species)
Actinopterygii - bony fishes (6 transcripts, 6 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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