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HomoloGene:11652. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PALB2,  H.sapiens
partner and localizer of BRCA2
    NP_078951.2
1186 aa
   PALB2,  P.troglodytes
partner and localizer of BRCA2
    XP_510877.2
1186 aa
   PALB2,  M.mulatta
partner and localizer of BRCA2
    XP_001095569.2
1135 aa
   PALB2,  C.lupus
partner and localizer of BRCA2
    XP_850671.2
1195 aa
   PALB2,  B.taurus
partner and localizer of BRCA2
    NP_001192544.1
1186 aa
   Palb2,  M.musculus
partner and localizer of BRCA2
    NP_001074707.1
1104 aa
   Palb2,  R.norvegicus
partner and localizer of BRCA2
    NP_001178532.1
1110 aa
   PALB2,  G.gallus
partner and localizer of BRCA2
    XP_004945321.1
1341 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Breast cancer, susceptibility to.
Fanconi anemia, complementation group N.



Publications
Articles associated with genes and sequences of this homology group.

Tumour morphology predicts PALB2 germline mutation status.
Teo ZL, et al. Br J Cancer 109, 154-63 (2013).
Hereditary breast cancer: beyond BRCA genetic analysis; PALB2 emerges.
Poumpouridou N & Kroupis C. Clin Chem Lab Med 50, 423-34 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
WD40 (cd00200)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
WD40 (cl02567)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
DD_superfamily (cl14633)
  The Death Domain Superfamily of protein-protein interaction domains.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Palb2 includes H.sapiens PALB2 and R.norvegicus Palb2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 9 species)

 

 

 

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