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HomoloGene:37926. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   EZH2,  H.sapiens
enhancer of zeste homolog 2 (Drosophila)
    NP_004447.2
751 aa
   EZH2,  P.troglodytes
enhancer of zeste homolog 2 (Drosophila)
    XP_001166174.2
746 aa
   EZH2,  M.mulatta
enhancer of zeste homolog 2 (Drosophila)
    XP_002803555.1
746 aa
   EZH2,  C.lupus
enhancer of zeste homolog 2 (Drosophila)
    XP_005629569.1
847 aa
   EZH2,  B.taurus
enhancer of zeste homolog 2 (Drosophila)
    NP_001179953.1
751 aa
   Ezh2,  M.musculus
enhancer of zeste homolog 2 (Drosophila)
    NP_031997.2
746 aa
   Ezh2,  R.norvegicus
enhancer of zeste homolog 2 (Drosophila)
    NP_001128451.1
746 aa
   EZH2,  G.gallus
enhancer of zeste homolog 2 (Drosophila)
    XP_418879.3
761 aa
   ezh2,  X.tropicalis
enhancer of zeste homolog 2
    NP_001017293.1
748 aa
   ezh2,  D.rerio
enhancer of zeste homolog 2 (Drosophila)
    NP_001070747.1
760 aa
   E(z),  D.melanogaster
Enhancer of zeste
    NP_001261682.1
765 aa
   AgaP_AGAP012516,  A.gambiae
AgaP_AGAP012516
    XP_307419.2
742 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Locus named after original gain-of-function allele E(z)1 (Kalisch and Rasmuson, 1974); subsequently designated polycombeotic (pco) (by Phillips and Shearn, 1980) based on phenotype of lethal homozygotes. Loss of function alleles recovered as (a) recessive lethal mutations (b) reversions of E(z)1 and (c) reversions of the antimorphic allele, E(z)59. Reduction of E(z)+ activity leads to suppression of the z eye color, whereas gain-of-function alleles are dominant enhancers of zeste eye color [i.e., z w+/Y; E(z)1/+ males have brownish eyes as do z w+/z+ w+; E(z)1/+ females]. (See FlyBase for complete description.)

H.sapiens
???.



Publications
Articles associated with genes and sequences of this homology group.

PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells.
Kaneko S, et al. Nat Struct Mol Biol 20, 1258-64 (2013).
EZH2 in normal and malignant hematopoiesis.
Lund K, et al. Leukemia 28, 44-9 (2014).
Promiscuous RNA binding by Polycomb repressive complex 2.
Davidovich C, et al. Nat Struct Mol Biol 20, 1250-7 (2013).
Expression of polycomb targets predicts breast cancer prognosis.
Jene-Sanz A, et al. Mol Cell Biol 33, 3951-61 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
EZH2_WD-Binding (pfam11616)
  WD repeat binding protein EZH2.
COG2940 (COG2940)
  Proteins containing SET domain [General function prediction only].
SET (cl02566)
  SET domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ezh2 includes H.sapiens EZH2 and R.norvegicus Ezh2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (16 transcripts, 9 species)
Mammalia - mammals (14 transcripts, 12 species)
Amphibia - amphibians (4 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 9 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Streptophyta
Eudicotyledons - eudicots (3 transcripts, 3 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)

 

 

 

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