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HomoloGene:3351. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NOTCH4,  H.sapiens
notch 4
    NP_004548.3
2003 aa
   NOTCH4,  P.troglodytes
notch 4
    XP_518380.3
2006 aa
   NOTCH4,  C.lupus
notch 4
    XP_005627807.1
1821 aa
   NOTCH4,  B.taurus
notch 4
    NP_001193877.1
1989 aa
   Notch4,  M.musculus
notch 4
    NP_035059.2
1964 aa
   Notch4,  R.norvegicus
notch 4
    NP_001002827.1
1961 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

NOTCH4 is a potential therapeutic target for triple-negative breast cancer.
Nagamatsu I, et al. Anticancer Res 34, 69-80 (2014).
Active form Notch4 promotes the proliferation and differentiation of 3T3-L1 preadipocytes.
Lai PY, et al. Biochem Biophys Res Commun 430, 1132-9 (2013).
Up-regulation of NOTCH4 gene expression in bipolar disorder.
Dieset I, et al. Am J Psychiatry 169, 1292-300 (2012).
A re-review of the association between the NOTCH4 locus and schizophrenia.
Shayevitz C, et al. Am J Med Genet B Neuropsychiatr Genet 159B, 477-83 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NOD (pfam06816)
  NOTCH protein.
NODP (pfam07684)
  NOTCH protein.
Notch (pfam00066)
  LNR domain.
ANK (cd00204)
  ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
NODP (pfam07684)
  NOTCH protein.
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
Notch (cl02419)
  LNR domain.
Cse1_I-E (cl08044)
  CRISPR/Cas system-associated protein Cse1.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Notch4 includes H.sapiens NOTCH4 and R.norvegicus Notch4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 9 species)

 

 

 

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