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HomoloGene:7567. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   PHF1,  H.sapiens
PHD finger protein 1
567 aa
   PHF1,  P.troglodytes
PHD finger protein 1
567 aa
   PHF1,  M.mulatta
PHD finger protein 1
567 aa
   PHF1,  C.lupus
PHD finger protein 1
567 aa
   PHF1,  B.taurus
PHD finger protein 1
567 aa
   Phf1,  M.musculus
PHD finger protein 1
559 aa
   Phf1,  R.norvegicus
PHD finger protein 1
560 aa
   phf1,  X.tropicalis
PHD finger protein 1
544 aa
   LOC100334345,  D.rerio
PHD finger protein 1-like
504 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1.
Musselman CA, et al. Nat Struct Mol Biol 19, 1266-72 (2012).
Recurrent rearrangement of the PHF1 gene in ossifying fibromyxoid tumors.
Gebre-Medhin S, et al. Am J Pathol 181, 1069-77 (2012).
Role of hPHF1 in H3K27 methylation and Hox gene silencing.
Cao R, et al. Mol Cell Biol 28, 1862-72 (2008).
Tudor domains of the PRC2 components PHF1 and PHF19 selectively bind to histone H3K36me3.
Qin S, et al. Biochem Biophys Res Commun 430, 547-53 (2013).
An endometrial stromal sarcoma cell line with the JAZF1/PHF1 chimera.
Panagopoulos I, et al. Cancer Genet Cytogenet 185, 74-7 (2008).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PHD (pfam00628)
Mtf2_C (pfam14061)
  Polycomb-like MTF2 factor 2.
TUDOR (cl02573)
  Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
PHD (cl17445)

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Phf1 includes H.sapiens PHF1 and R.norvegicus Phf1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (11 transcripts, 11 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)

Insecta - insects (3 transcripts, 3 species)
Arachnida - arachnids (1 transcript, 1 species)




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