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HomoloGene:10352. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TREM2,  H.sapiens
triggering receptor expressed on myeloid cells 2
    NP_061838.1
230 aa
   TREM2,  P.troglodytes
triggering receptor expressed on myeloid cells 2
    XP_001174118.2
260 aa
   TREM2,  M.mulatta
triggering receptor expressed on myeloid cells 2
    XP_001117305.2
260 aa
   TREM2,  C.lupus
triggering receptor expressed on myeloid cells 2
    XP_005627370.1
230 aa
   TREM2,  B.taurus
triggering receptor expressed on myeloid cells 2
    NP_001073048.1
230 aa
   Trem2,  M.musculus
triggering receptor expressed on myeloid cells 2
    NP_112544.1
227 aa
   TREM2,  G.gallus
triggering receptor expressed on myeloid cells 2
    NP_001032921.1
221 aa
   trem2,  X.tropicalis
triggering receptor expressed on myeloid cells 2
    NP_001103522.1
240 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Nasu-Hakola disease.



Publications
Articles associated with genes and sequences of this homology group.

TREM2 and neurodegenerative disease.
Benitez BA, et al. N Engl J Med 369, 1567-8 (2013).
Insights into TREM2 biology by network analysis of human brain gene expression data.
Forabosco P, et al. Neurobiol Aging 34, 2699-714 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ig (cl11960)
  Immunoglobulin domain.
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Trem2 includes H.sapiens TREM2 and R.norvegicus Trem2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 7 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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