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HomoloGene:3681. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PDCD1,  H.sapiens
programmed cell death 1
    NP_005009.2
288 aa
   PDCD1,  P.troglodytes
programmed cell death 1
    XP_003950066.1
163 aa
   PDCD1,  M.mulatta
programmed cell death 1
    NP_001107830.1
288 aa
   PDCD1,  C.lupus
programmed cell death 1
    XP_543338.3
288 aa
   PDCD1,  B.taurus
programmed cell death 1
    NP_001076975.1
282 aa
   Pdcd1,  M.musculus
programmed cell death 1
    NP_032824.1
288 aa
   LOC102550808,  R.norvegicus
programmed cell death protein 1-like
    XP_006245633.1
286 aa
   Pdcd1,  R.norvegicus
programmed cell death 1
    NP_001100397.1
287 aa
   PDCD1,  G.gallus
programmed cell death 1
    XP_422723.3
304 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Systemic lupus erythematosus, susceptibility to, 2}, 605218.



Publications
Articles associated with genes and sequences of this homology group.

PD-1 dependent exhaustion of CD8+ T cells drives chronic malaria.
Horne-Debets JM, et al. Cell Rep 5, 1204-13 (2013).
PD-1 blockage delays murine squamous cell carcinoma development.
Belai EB, et al. Carcinogenesis 35, 424-31 (2014).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ig (cl11960)
  Immunoglobulin domain.
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pdcd1 includes H.sapiens PDCD1 and R.norvegicus Pdcd1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (6 transcripts, 6 species)

 

 

 

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