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HomoloGene:37990. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   KRAS,  H.sapiens
Kirsten rat sarcoma viral oncogene homolog
    NP_203524.1
189 aa
   KRAS,  P.troglodytes
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
    XP_003313842.1
189 aa
   KRAS,  C.lupus
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
    XP_003433608.2
227 aa
   KRAS,  B.taurus
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
    NP_001103471.1
188 aa
   Kras,  M.musculus
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
    NP_067259.4
188 aa
   Kras,  R.norvegicus
Kirsten rat sarcoma viral oncogene
    NP_113703.1
188 aa
   KRAS,  G.gallus
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
    NP_001243091.1
188 aa
   LOC100485959,  X.tropicalis
GTPase KRas-like
    XP_004920180.1
226 aa
   kras,  D.rerio
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
    NP_001003744.1
188 aa
   Ras85D,  D.melanogaster
Ras oncogene at 85D
    NP_476699.1
189 aa
   AgaP_AGAP002219,  A.gambiae
AgaP_AGAP002219
    XP_307965.4
190 aa
   let-60,  C.elegans
let-60
    NP_502213.3
184 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Codes for a polypeptide of 21.6 kilodaltons; residues 1-121 and 137-64 exhibit 75% homology with vertebrate H-ras protein.

H.sapiens
Bladder cancer.
Breast cancer, somatic.
Stomach cancer.
Leukemia, acute myelogenous.
Lung cancer.
Costello syndrome.
Pancreatic carcinoma, somatic.
Noonan syndrome 3.



Publications
Articles associated with genes and sequences of this homology group.

Mutant KRAS is a druggable target for pancreatic cancer.
Zorde Khvalevsky E, et al. Proc Natl Acad Sci U S A 110, 20723-8 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ras_like_GTPase (cl17170)
  Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Kras includes H.sapiens KRAS and R.norvegicus Kras.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 9 species)
Actinopterygii - bony fishes (9 transcripts, 8 species)
Amphibia - amphibians (9 transcripts, 2 species)
Aves - birds (3 transcripts, 3 species)
Amniota - vertebrates (2 transcripts, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 10 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (2 transcripts, 2 species)
Coniferopsida - conifers (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (2 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

 

 

 

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