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HomoloGene:20242. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   HTR2C,  H.sapiens
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
    NP_001243689.1
458 aa
   HTR2C,  P.troglodytes
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
    NP_001029104.2
458 aa
   HTR2C,  M.mulatta
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
    XP_001101997.1
458 aa
   HTR2C,  C.lupus
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
    NP_001006649.1
458 aa
   HTR2C,  B.taurus
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
    XP_005227998.1
434 aa
   Htr2c,  M.musculus
5-hydroxytryptamine (serotonin) receptor 2C
    NP_032338.3
459 aa
   Htr2c,  R.norvegicus
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
    NP_036897.2
460 aa
   GPR5HT2A,  A.gambiae
GPR5HT2A
    XP_307953.2
735 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Impact of serotonin (5-HT)2C receptors on executive control processes.
Pennanen L, et al. Neuropsychopharmacology 38, 957-67 (2013).
Impulsive action in the 5-choice serial reaction time test in 5-HT₂c receptor null mutant mice.
Fletcher PJ, et al. Psychopharmacology (Berl) 226, 561-70 (2013).
Association between HTR2C polymorphisms and obesity in patients without antipsychotic drugs.
Risselada AJ, et al. J Clin Psychopharmacol 32, 715-40 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Htr2c includes H.sapiens HTR2C and R.norvegicus Htr2c.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 10 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

 

 

 

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