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HomoloGene:20148. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   HTR1A,  H.sapiens
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
    NP_000515.2
422 aa
   HTR1A,  P.troglodytes
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
    NP_001129094.1
422 aa
   HTR1A,  M.mulatta
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
    XP_001083407.1
421 aa
   HTR1A,  C.lupus
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
    NP_001012397.1
423 aa
   HTR1A,  B.taurus
5-hydroxytryptamine (serotonin) receptor 1A
    XP_002696350.1
422 aa
   Htr1a,  M.musculus
5-hydroxytryptamine (serotonin) receptor 1A
    NP_032334.2
421 aa
   Htr1a,  R.norvegicus
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
    NP_036717.1
422 aa
   HTR1A,  G.gallus
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
    NP_001163999.1
413 aa
   htr1a,  X.tropicalis
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
    XP_004910432.1
410 aa
   htr1aa,  D.rerio
5-hydroxytryptamine (serotonin) receptor 1A a
    NP_001116793.1
398 aa
   5-HT1A,  D.melanogaster
Serotonin receptor 1A
    NP_725849.1
834 aa
   GPR5HT1A,  A.gambiae
GPR5HT1A
    XP_308623.4
564 aa
   ser-4,  C.elegans
ser-4
    NP_497452.1
445 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Serotonin 1A auto-receptors are not sufficient to modulate anxiety in mice.
Piszczek L, et al. Eur J Neurosci 38, 2621-7 (2013).
Serotonin 1A receptors alter expression of movement representations.
Scullion K, et al. J Neurosci 33, 4988-99 (2013).
Reduced post-synaptic serotonin type 1A receptor binding in bipolar depression.
Nugent AC, et al. Eur Neuropsychopharmacol 23, 822-9 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Htr1a includes H.sapiens HTR1A and R.norvegicus Htr1a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 10 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 4 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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