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HomoloGene:6221. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   VPS35,  H.sapiens
vacuolar protein sorting 35 homolog (S. cerevisiae)
    NP_060676.2
796 aa
   VPS35,  P.troglodytes
vacuolar protein sorting 35 homolog (S. cerevisiae)
    XP_001161536.1
796 aa
   VPS35,  M.mulatta
vacuolar protein sorting 35 homolog (S. cerevisiae)
    XP_001108828.2
707 aa
   VPS35,  C.lupus
vacuolar protein sorting 35 homolog (S. cerevisiae)
    XP_532570.3
796 aa
   VPS35,  B.taurus
vacuolar protein sorting 35 homolog (S. cerevisiae)
    NP_001039723.1
796 aa
   Vps35,  M.musculus
vacuolar protein sorting 35
    NP_075373.1
796 aa
   Vps35,  R.norvegicus
vacuolar protein sorting 35 homolog (S. cerevisiae)
    NP_001099188.2
796 aa
   VPS35,  G.gallus
vacuolar protein sorting 35 homolog (S. cerevisiae)
    NP_001005842.1
796 aa
   vps35,  D.rerio
vacuolar protein sorting 35 (yeast)
    NP_001020688.2
831 aa
   Vps35,  D.melanogaster
Vacuolar protein sorting 35
    NP_611651.4
803 aa
   AgaP_AGAP007683,  A.gambiae
AgaP_AGAP007683
    XP_308188.4
810 aa
   vps-35,  C.elegans
vps-35
    NP_495180.2
821 aa
   VPS35,  S.cerevisiae
VPS35
    NP_012381.1
944 aa
   KLLA0B07535g,  K.lactis
KLLA0B07535g
    XP_451864.1
879 aa
   AGOS_AEL107W,  E.gossypii
AGOS_AEL107W
    NP_984754.1
889 aa
   vps35,  S.pombe
vps35
    NP_588260.2
836 aa
   MGG_05089,  M.oryzae
MGG_05089
    XP_003712611.1
898 aa
   NCU06284,  N.crassa
NCU06284
    XP_962546.1
881 aa
   VPS35B,  A.thaliana
VPS35B
    NP_177713.3
790 aa
   Os03g0801600,  O.sativa
Os03g0801600
    NP_001051593.1
793 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
???.



Publications
Articles associated with genes and sequences of this homology group.

The VPS35 gene and Parkinson's disease.
Deng H, et al. Mov Disord 28, 569-75 (2013).
Frequency of the D620N mutation in VPS35 in Parkinson disease.
Kumar KR, et al. Arch Neurol 69, 1360-4 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Vps35 (pfam03635)
  Vacuolar protein sorting-associated protein 35.
Vps35 (pfam03635)
  Vacuolar protein sorting-associated protein 35.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Vps35 includes H.sapiens VPS35 and R.norvegicus Vps35.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (77 transcripts, 28 species)
Liliopsida - monocots (12 transcripts, 9 species)
Coniferopsida - conifers (4 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Chordata
Mammalia - mammals (21 transcripts, 17 species)
Actinopterygii - bony fishes (16 transcripts, 12 species)
Aves - birds (3 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 11 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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