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HomoloGene:1095. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   EPAS1,  H.sapiens
endothelial PAS domain protein 1
870 aa
   EPAS1,  P.troglodytes
endothelial PAS domain protein 1
870 aa
   EPAS1,  M.mulatta
endothelial PAS domain protein 1
832 aa
   EPAS1,  C.lupus
endothelial PAS domain protein 1
873 aa
   EPAS1,  B.taurus
endothelial PAS domain protein 1
870 aa
   Epas1,  M.musculus
endothelial PAS domain protein 1
874 aa
   Epas1,  R.norvegicus
endothelial PAS domain protein 1
874 aa
   EPAS1,  G.gallus
endothelial PAS domain protein 1
867 aa
   epas1,  X.tropicalis
endothelial PAS domain protein 1
862 aa
   epas1b,  D.rerio
endothelial PAS domain protein 1b
832 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DAG1 (pfam05454)
  Dystroglycan (Dystrophin-associated glycoprotein 1).
HIF-1a_CTAD (pfam08778)
  HIF-1 alpha C terminal transactivation domain.
HIF-1 (pfam11413)
  Hypoxia-inducible factor-1.
PAS_3 (pfam08447)
  PAS fold.
PAS (cd00130)
  PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
PAS_11 (pfam14598)
  PAS domain.
HLH (cl00081)
  Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Epas1 includes H.sapiens EPAS1 and R.norvegicus Epas1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (16 transcripts, 12 species)
Actinopterygii - bony fishes (9 transcripts, 7 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)




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