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HomoloGene:37664. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PRKAR1A,  H.sapiens
protein kinase, cAMP-dependent, regulatory, type I, alpha
    NP_997637.1
381 aa
   PRKAR1A,  P.troglodytes
protein kinase, cAMP-dependent, regulatory, type I, alpha
    XP_003315746.1
381 aa
   LOC719021,  M.mulatta
cAMP-dependent protein kinase type I-alpha regulatory subunit-like
    XP_001112547.2
464 aa
   PRKAR1A,  C.lupus
protein kinase, cAMP-dependent, regulatory, type I, alpha
    XP_005624335.1
381 aa
   PRKAR1A,  B.taurus
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
    NP_001069826.1
380 aa
   Prkar1a,  M.musculus
protein kinase, cAMP dependent regulatory, type I, alpha
    NP_068680.1
381 aa
   Prkar1a,  R.norvegicus
protein kinase, cAMP-dependent, regulatory, type I, alpha
    NP_037313.1
381 aa
   PRKAR1A,  G.gallus
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
    NP_001007846.1
382 aa
   prkar1a,  X.tropicalis
protein kinase, cAMP-dependent, regulatory, type I, alpha
    NP_001025530.1
381 aa
   prkar1ab,  D.rerio
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b
    NP_001017732.1
379 aa
   prkar1aa,  D.rerio
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a
    NP_001009989.1
379 aa
   Pka-R1,  D.melanogaster
cAMP-dependent protein kinase R1
    NP_730573.2
376 aa
   AgaP_AGAP006448,  A.gambiae
AgaP_AGAP006448
    XP_001688871.1
373 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Carney complex, type 1.
Thyroid carcinoma, papillary.
Adrenocortical tumor, somatic.
Myxoma, intracardiac.
Pigmented adrenocortical disease, primary, 1.



Publications
Articles associated with genes and sequences of this homology group.

Threat bias in mice with inactivating mutations of Prkar1a.
Keil MF, et al. Neuroscience 241, 206-14 (2013).
Prkar1a in the regulation of insulin secretion.
Hussain MA, et al. Horm Metab Res 44, 759-65 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CAP_ED (cl00047)
  effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
DD_R_PKA (cl02594)
  Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Prkar1a includes H.sapiens PRKAR1A and R.norvegicus Prkar1a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 17 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Aves - birds (3 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

 

 

 

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