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HomoloGene:228. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NPC1,  H.sapiens
Niemann-Pick disease, type C1
    NP_000262.2
1278 aa
   NPC1,  P.troglodytes
Niemann-Pick disease, type C1
    XP_001155285.1
1277 aa
   NPC1,  M.mulatta
Niemann-Pick disease, type C1
    XP_002800934.1
1257 aa
   NPC1,  C.lupus
Niemann-Pick disease, type C1
    NP_001003107.1
1276 aa
   NPC1,  B.taurus
Niemann-Pick disease, type C1
    NP_777183.1
1277 aa
   Npc1,  M.musculus
Niemann Pick type C1
    NP_032746.2
1277 aa
   Npc1,  R.norvegicus
Niemann-Pick disease, type C1
    NP_705888.2
1278 aa
   NPC1,  G.gallus
Niemann-Pick disease, type C1
    XP_419162.3
1286 aa
   npc1,  X.tropicalis
Niemann-Pick disease, type C1
    XP_004915269.1
1283 aa
   npc1,  D.rerio
Niemann-Pick disease, type C1
    NP_001230804.1
1271 aa
   Npc1a,  D.melanogaster
Niemann-Pick type C-1a
    NP_001188769.1
1287 aa
   AgaP_AGAP008137,  A.gambiae
AgaP_AGAP008137
    XP_317322.4
1192 aa
   NCR1,  S.cerevisiae
NCR1
    NP_015319.1
1170 aa
   KLLA0F27137g,  K.lactis
KLLA0F27137g
    XP_456287.1
1177 aa
   AGOS_AGL008W,  E.gossypii
AGOS_AGL008W
    NP_986658.1
1178 aa
   MGG_00819,  M.oryzae
MGG_00819
    XP_003718164.1
1275 aa
   NCU04090,  N.crassa
NCU04090
    XP_956086.1
1162 aa
   AT4G38350,  A.thaliana
AT4G38350
    NP_001190953.1
1297 aa
   AT1G42470,  A.thaliana
AT1G42470
    NP_174975.2
1272 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Niemann-Pick disease, type C1.
Niemann-Pick disease, type D.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Sterol-sensing (pfam12349)
  Sterol-sensing domain of SREBP cleavage-activation.
Sterol-sensing (pfam12349)
  Sterol-sensing domain of SREBP cleavage-activation.
MMPL (cl14618)
  MMPL family.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Npc1 includes H.sapiens NPC1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 12 species)
Actinopterygii - bony fishes (11 transcripts, 8 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (15 transcripts, 10 species)
Arachnida - arachnids (5 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (4 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (36 transcripts, 21 species)
Liliopsida - monocots (6 transcripts, 5 species)
Coniferopsida - conifers (4 transcripts, 3 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Oomycetes
Pythiales - oomycetes (4 transcripts, 1 species)
Peronosporales - oomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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