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HomoloGene:55485. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CHRNA5,  H.sapiens
cholinergic receptor, nicotinic, alpha 5 (neuronal)
    NP_000736.2
468 aa
   CHRNA5,  P.troglodytes
cholinergic receptor, nicotinic, alpha 5 (neuronal)
    NP_001029106.1
468 aa
   CHRNA5,  M.mulatta
cholinergic receptor, nicotinic, alpha 5 (neuronal)
    XP_001108279.1
466 aa
   CHRNA5,  C.lupus
cholinergic receptor, nicotinic, alpha 5 (neuronal)
    XP_005628378.1
488 aa
   CHRNA5,  B.taurus
cholinergic receptor, nicotinic, alpha 5
    NP_776939.1
475 aa
   Chrna5,  M.musculus
cholinergic receptor, nicotinic, alpha polypeptide 5
    NP_789814.2
438 aa
   Chrna5,  R.norvegicus
cholinergic receptor, nicotinic, alpha 5 (neuronal)
    NP_058774.2
467 aa
   CHRNA5,  G.gallus
cholinergic receptor, nicotinic, alpha 5 (neuronal)
    NP_989746.1
454 aa
   chrna5,  X.tropicalis
cholinergic receptor, nicotinic, alpha 5 (neuronal)
    XP_002937929.1
476 aa
   chrna5,  D.rerio
cholinergic receptor, nicotinic, alpha 5
    NP_001017885.1
466 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Lung cancer susceptibility 2.



Publications
Articles associated with genes and sequences of this homology group.

Nicotinic acetylcholine receptor variation and response to smoking cessation therapies.
Bergen AW, et al. Pharmacogenet Genomics 23, 94-103 (2013).
Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.
Hartz SM, et al. Arch Gen Psychiatry 69, 854-60 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Neur_chan_memb (pfam02932)
  Neurotransmitter-gated ion-channel transmembrane region.
Neur_chan_LBD (pfam02931)
  Neurotransmitter-gated ion-channel ligand binding domain.
Neur_chan_memb (pfam02932)
  Neurotransmitter-gated ion-channel transmembrane region.
Neur_chan_LBD (pfam02931)
  Neurotransmitter-gated ion-channel ligand binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Chrna5 includes H.sapiens CHRNA5 and R.norvegicus Chrna5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 8 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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