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HomoloGene:1577. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GRN,  H.sapiens
granulin
    NP_002078.1
593 aa
   GRN,  P.troglodytes
granulin
    XP_511549.2
501 aa
   LOC714851,  M.mulatta
granulins-like
    XP_002808178.1
593 aa
   GRN,  B.taurus
granulin
    NP_001070482.1
587 aa
   Grn,  M.musculus
granulin
    NP_032201.2
602 aa
   Grn,  R.norvegicus
granulin
    NP_058809.2
602 aa
   grn,  X.tropicalis
granulin
    NP_001072169.1
1161 aa
   grna,  D.rerio
granulin a
    XP_005164021.1
1138 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Frontotemporal dementia, ubiquitin-positive.



Publications
Articles associated with genes and sequences of this homology group.

Screening for progranulin mutations by serum protein dosage in common neurodegenerative disorders.
Rodríguez-Rodríguez E, et al. Parkinsonism Relat Disord 19, 768-9 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Granulin (cl02546)
  Granulin.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Grn includes H.sapiens GRN and R.norvegicus Grn.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 8 species)
Actinopterygii - bony fishes (5 transcripts, 3 species)
Ascidiacea - tunicates (3 transcripts, 3 species)

Platyhelminthes
Trematoda - flatworms (4 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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