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HomoloGene:30960. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NR3C1,  H.sapiens
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
    NP_001019265.1
778 aa
   NR3C1,  P.troglodytes
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
    XP_001154855.1
777 aa
   NR3C1,  M.mulatta
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
    XP_001097126.1
777 aa
   NR3C1,  C.lupus
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
    XP_005617392.1
781 aa
   NR3C1,  B.taurus
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
    NP_001193563.1
781 aa
   Nr3c1,  M.musculus
nuclear receptor subfamily 3, group C, member 1
    NP_032199.3
792 aa
   Nr3c1,  R.norvegicus
nuclear receptor subfamily 3, group C, member 1
    NP_036708.2
794 aa
   NR3C1,  G.gallus
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
    NP_001032915.1
772 aa
   nr3c1,  X.tropicalis
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
    NP_001016967.1
778 aa
   nr3c1,  D.rerio
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
    NP_001018547.2
746 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cortisol resistance.



Publications
Articles associated with genes and sequences of this homology group.

Glucocorticoids and their receptors: insights into specific roles in mitochondria.
Lee SR, et al. Prog Biophys Mol Biol 112, 44-54 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
GCR (pfam02155)
  Glucocorticoid receptor.
NR_DBD_like (cl02596)
  DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers.
NR_LBD (cl11397)
  The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nr3c1 includes H.sapiens NR3C1 and R.norvegicus Nr3c1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 14 species)
Actinopterygii - bony fishes (14 transcripts, 8 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

 

 

 

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