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HomoloGene:77038. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   WISP3,  H.sapiens
WNT1 inducible signaling pathway protein 3
    NP_937882.1
372 aa
   WISP3,  P.troglodytes
WNT1 inducible signaling pathway protein 3
    XP_001159727.2
372 aa
   WISP3,  M.mulatta
WNT1 inducible signaling pathway protein 3
    XP_001083520.1
372 aa
   WISP3,  B.taurus
WNT1 inducible signaling pathway protein 3
    XP_003586513.1
354 aa
   Wisp3,  M.musculus
WNT1 inducible signaling pathway protein 3
    NP_001120848.1
354 aa
   Wisp3,  R.norvegicus
WNT1 inducible signaling pathway protein 3
    NP_001163954.1
354 aa
   WISP3,  G.gallus
WNT1 inducible signaling pathway protein 3
    XP_001234150.2
342 aa
   wisp3,  X.tropicalis
WNT1 inducible signaling pathway protein 3
    XP_002936979.2
368 aa
   wisp3,  D.rerio
WNT1 inducible signaling pathway protein 3
    NP_001159703.1
338 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Arthropathy, progressive pseudorheumatoid, of childhood.
Spondyloepiphyseal dysplasia tarda with progressive arthropathy.



Publications
Articles associated with genes and sequences of this homology group.

A homozygous recurring mutation in WISP3 causing progressive pseudorheumatoid arthropathy.
Temiz F, et al. J Pediatr Endocrinol Metab 24, 105-8 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IGFBP (pfam00219)
  Insulin-like growth factor binding protein.
GHB_like (cl00070)
  Glycoprotein hormone beta chain homologues.
TSP_1 (cl15278)
  Thrombospondin type 1 domain.
DAN (cl17734)
  DAN domain.
IGFBP (cl02472)
  Insulin-like growth factor binding protein.
TSP_1 (cl15278)
  Thrombospondin type 1 domain.
DAN (cl17734)
  DAN domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Wisp3 includes H.sapiens WISP3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 7 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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