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HomoloGene:3684. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   PFN1,  H.sapiens
profilin 1
140 aa
   PFN1,  P.troglodytes
profilin 1
114 aa
   PFN1,  M.mulatta
profilin 1
140 aa
   PFN1,  B.taurus
profilin 1
140 aa
   Pfn1,  M.musculus
profilin 1
140 aa
   Pfn1,  R.norvegicus
profilin 1
140 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.


Articles associated with genes and sequences of this homology group.

Profilin-1 mutations are rare in patients with amyotrophic lateral sclerosis and frontotemporal dementia.
van Blitterswijk M, et al. Amyotroph Lateral Scler Frontotemporal Degener 14, 463-9 (2013).
Profilin-1 promotes the development of hypertension-induced cardiac hypertrophy.
Zhao SH, et al. J Hypertens 31, 576-86; discussion 586 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PROF (cl00123)
  Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pfn1 includes H.sapiens PFN1 and R.norvegicus Pfn1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (19 transcripts, 13 species)
Aves - birds (3 transcripts, 2 species)




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