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HomoloGene:3197. Gene conserved in Bilateria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   BRAF,  H.sapiens
v-raf murine sarcoma viral oncogene homolog B
766 aa
   BRAF,  P.troglodytes
v-raf murine sarcoma viral oncogene homolog B1
767 aa
   LOC693554,  M.mulatta
serine/threonine-protein kinase B-raf-like
686 aa
   BRAF,  C.lupus
v-raf murine sarcoma viral oncogene homolog B1
617 aa
   BRAF,  B.taurus
v-raf murine sarcoma viral oncogene homolog B
766 aa
   Braf,  M.musculus
Braf transforming gene
804 aa
   Braf,  R.norvegicus
v-raf murine sarcoma viral oncogene homolog B
837 aa
   BRAF,  G.gallus
v-raf murine sarcoma viral oncogene homolog B1
806 aa
   braf,  X.tropicalis
v-raf murine sarcoma viral oncogene homolog B
772 aa
   braf,  D.rerio
v-raf murine sarcoma viral oncogene homolog B1
777 aa
   phl,  D.melanogaster
pole hole
739 aa
   AgaP_AGAP004699,  A.gambiae
667 aa
   lin-45,  C.elegans
813 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

The wild-type allele of phl seems to be involved in the setting up of positional values in embryos and also in the proliferation of diploid cells in imaginal discs (Ambrosio, Mahowald and Perrimon, 1989a). phl mutants are recessive early-pupal lethals, which display very small imaginal discs. Embryos derived from germ-line clones and lacking phl+ activity show the 'torso' or 'pole hole' phenotype; structures at the anterior and the posterior end (spiracles, anal tufts and the entire eighth abdominal segment) fail to develop (Perrimon, Engstrom and Mahowald, 1984a; Perrimon, Engstrom and Mahowald, 1984b; Ambrosio, Mahowald and Perrimon, 1989a). (See FlyBase for complete description.)

Cardiofaciocutaneous syndrome.
Colorectal cancer, somatic.
Melanoma, melignant, somatic.
Nonsmall cell lung cancer, somatic.
Adenocarcinoma of lung, somatic.

Articles associated with genes and sequences of this homology group.

B-Raf mutation: a key player in molecular biology of cancer.
Rahman MA, et al. Exp Mol Pathol 95, 336-42 (2013).
BRAF mutation in sporadic colorectal cancer and Lynch syndrome.
Thiel A, et al. Virchows Arch 463, 613-21 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Pkinase (pfam00069)
  Protein kinase domain.
Pkinase_Tyr (pfam07714)
  Protein tyrosine kinase.
UBQ (cl00155)
  Ubiquitin-like proteins.
Pkinase (pfam00069)
  Protein kinase domain.
C1 (cl00040)
  Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
UBQ (cl00155)
  Ubiquitin-like proteins.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Braf includes H.sapiens BRAF and R.norvegicus Braf.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (8 transcripts, 8 species)
Actinopterygii - bony fishes (7 transcripts, 7 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Insecta - insects (7 transcripts, 7 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Chromadorea - nematodes (2 transcripts, 2 species)

Hirudinida - segmented worms (1 transcript, 1 species)




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