Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:32215. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   DDX58,  H.sapiens
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
    NP_055129.2
925 aa
   DDX58,  P.troglodytes
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
    XP_001156662.1
925 aa
   DDX58,  M.mulatta
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
    NP_001036133.1
925 aa
   DDX58,  C.lupus
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
    XP_003639433.1
923 aa
   DDX58,  B.taurus
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
    XP_002689526.2
1017 aa
   Ddx58,  M.musculus
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
    NP_766277.3
926 aa
   ddx58,  X.tropicalis
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
    XP_002935717.2
966 aa
   drh-1,  C.elegans
drh-1
    NP_501018.1
1037 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

RIG-I-like receptors mediate innate antiviral response in mouse testis.
Zhu W, et al. Mol Endocrinol 27, 1455-67 (2013).
RIG-I activation inhibits HIV replication in macrophages.
Wang Y, et al. J Leukoc Biol 94, 337-41 (2013).
Intracellular pathogen detection by RIG-I-like receptors.
Dixit E & Kagan JC. Adv Immunol 117, 99-125 (2013).
Rig-I regulates NF-κB activity through binding to Nf-κb1 3'-UTR mRNA.
Zhang HX, et al. Proc Natl Acad Sci U S A 110, 6459-64 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CARD_RIG-I_2 (cd08817)
  Caspase activation and recruitment domain found in RIG-I, second repeat.
HTH (cl00088)
  Helix-turn-helix domains.
helicase_insert_domain (cl17041)
  helical domain inserted in SF2-type helicase domain in Hef-, MDA5- and FancM-like proteins.
RIG-I_C-RD (pfam11648)
  C-terminal domain of RIG-I.
HELICc (cd00079)
  Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
DD_superfamily (cl14633)
  The Death Domain Superfamily of protein-protein interaction domains.
RIG-I_C-RD (pfam11648)
  C-terminal domain of RIG-I.
DD (cl14633)
  Death Domain Superfamily of protein-protein interaction domains.
DEXDc (cl17251)
  DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ddx58 includes H.sapiens DDX58.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 6 species)
Amniota - vertebrates (1 transcript, 1 species)
Actinopterygii - bony fishes (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

Write to the Help Desk