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HomoloGene:265. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PTEN,  H.sapiens
phosphatase and tensin homolog
    NP_000305.3
403 aa
   PTEN,  P.troglodytes
phosphatase and tensin homolog
    XP_521544.3
403 aa
   PTEN,  M.mulatta
phosphatase and tensin homolog
    XP_001102542.1
403 aa
   PTEN,  C.lupus
phosphatase and tensin homolog
    NP_001003192.1
403 aa
   PTEN,  B.taurus
phosphatase and tensin homolog
    XP_002698416.1
403 aa
   Pten,  M.musculus
phosphatase and tensin homolog
    NP_032986.1
403 aa
   Pten,  R.norvegicus
phosphatase and tensin homolog
    NP_113794.1
403 aa
   PTEN,  G.gallus
phosphatase and tensin homolog
    XP_421555.2
403 aa
   pten,  X.tropicalis
phosphatase and tensin homolog
    NP_001116943.1
402 aa
   ptenb,  D.rerio
phosphatase and tensin homolog B
    NP_001001822.1
399 aa
   Pten,  D.melanogaster
Pten
    NP_001162933.1
514 aa
   AgaP_AGAP009628,  A.gambiae
AgaP_AGAP009628
    XP_553421.2
324 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Oligodendroglioma.
Bannayan-Riley-Ruvalcaba syndrome.
Cowden disease.
Juvenile polyposis syndrome, infantile form.
Prostate cancer.
Proteus syndrome.
Thyroid carcinoma, follicular.
VATER association with hydrocephalus.
Endometrial carcinoma.
Lhermitte-Duclos syndrome.
Macrocephaly/autism syndrome.
Meningioma.



Publications
Articles associated with genes and sequences of this homology group.

Comprehensive analysis of PTEN status in Sezary syndrome.
Cristofoletti C, et al. Blood 122, 3511-20 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PTEN_C2 (pfam10409)
  C2 domain of PTEN tumour-suppressor protein.
CDC14 (COG2453)
  Predicted protein-tyrosine phosphatase [Signal transduction mechanisms].
PTPc (cl00053)
  Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
PTEN_C2 (pfam10409)
  C2 domain of PTEN tumor-suppressor protein.
DSPc (cl00053)
  Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pten includes H.sapiens PTEN and R.norvegicus Pten.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (25 transcripts, 11 species)
Mammalia - mammals (18 transcripts, 14 species)
Aves - birds (4 transcripts, 3 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (4 transcripts, 4 species)

Echinodermata
Echinoidea - sea urchins (4 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (4 transcripts, 1 species)

Streptophyta
Eudicotyledons - eudicots (3 transcripts, 3 species)

Ciliophora
Oligohymenophorea - ciliates (3 transcripts, 2 species)

Ascomycota
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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