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HomoloGene:1925. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   P2RX7,  H.sapiens
purinergic receptor P2X, ligand-gated ion channel, 7
    NP_002553.3
595 aa
   P2RX7,  P.troglodytes
purinergic receptor P2X, ligand-gated ion channel, 7
    XP_509436.2
595 aa
   P2RX7,  M.mulatta
purinergic receptor P2X, ligand-gated ion channel, 7
    XP_001092531.1
595 aa
   P2RX7,  C.lupus
purinergic receptor P2X, ligand-gated ion channel, 7
    NP_001106927.1
595 aa
   P2RX7,  B.taurus
purinergic receptor P2X, ligand-gated ion channel, 7
    NP_001193445.1
595 aa
   P2rx7,  M.musculus
purinergic receptor P2X, ligand-gated ion channel, 7
    NP_035157.2
595 aa
   P2RX7,  G.gallus
purinergic receptor P2X, ligand-gated ion channel, 7
    XP_001235163.3
560 aa
   LOC100490662,  X.tropicalis
P2X purinoceptor 7-like
    XP_002937745.1
565 aa
   LOC100490828,  X.tropicalis
P2X purinoceptor 7-like
    XP_002937746.1
568 aa
   p2rx7,  D.rerio
purinergic receptor P2X, ligand-gated ion channel, 7
    NP_945335.1
596 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Leukemia, chronic lymphatic, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

P2X7 receptors regulate engulfing activity of non-stimulated resting astrocytes.
Yamamoto M, et al. Biochem Biophys Res Commun 439, 90-5 (2013).
Assessment of mercury chloride-induced toxicity and the relevance of P2X7 receptor activation in zebrafish larvae.
Cruz FF, et al. Comp Biochem Physiol C Toxicol Pharmacol 158, 159-64 (2013).
Cathelicidin antimicrobial peptide inhibits fibroblast migration via P2X7 receptor signaling.
Kumagai S, et al. Biochem Biophys Res Commun 437, 609-14 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Keratin_matx (pfam04579)
  Keratin, high-sulphur matrix protein.
P2X_receptor (pfam00864)
  ATP P2X receptor.
P2X_receptor (cl02993)
  ATP P2X receptor.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus P2rx7 includes H.sapiens P2RX7 and R.norvegicus P2rx7.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 10 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)

 

 

 

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