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HomoloGene:11469. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CARD14,  H.sapiens
caspase recruitment domain family, member 14
    NP_077015.2
1004 aa
   CARD14,  P.troglodytes
caspase recruitment domain family, member 14
    XP_511725.3
962 aa
   CARD14,  M.mulatta
caspase recruitment domain family, member 14
    XP_001110299.1
740 aa
   CARD14,  C.lupus
caspase recruitment domain family, member 14
    XP_540472.3
1007 aa
   CARD14,  B.taurus
caspase recruitment domain family, member 14
    NP_001192830.1
1002 aa
   Card14,  M.musculus
caspase recruitment domain family, member 14
    NP_570956.1
999 aa
   Card14,  R.norvegicus
caspase recruitment domain family, member 14
    XP_006248022.1
943 aa
   card14,  X.tropicalis
caspase recruitment domain family, member 14
    XP_002937355.2
972 aa
   card14,  D.rerio
caspase recruitment domain family, member 14
    XP_697127.4
985 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
???.



Publications
Articles associated with genes and sequences of this homology group.

Familial pityriasis rubra pilaris is caused by mutations in CARD14.
Fuchs-Telem D, et al. Am J Hum Genet 91, 163-70 (2012).
PSORS2 is due to mutations in CARD14.
Jordan CT, et al. Am J Hum Genet 90, 784-95 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TPR_MLP1_2 (pfam07926)
  TPR/MLP1/MLP2-like protein.
CARD_CARD14_CARMA2 (cd08806)
  Caspase activation and recruitment domain of CARD14-like proteins.
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
DD_superfamily (cl14633)
  The Death Domain Superfamily of protein-protein interaction domains.
SH3 (cl17036)
  Src Homology 3 domain superfamily.
NK (cl17190)
  Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
TPR_MLP1_2 (pfam07926)
  TPR/MLP1/MLP2-like protein.
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
DD (cl14633)
  Death Domain Superfamily of protein-protein interaction domains.
SH3 (cl17036)
  Src Homology 3 domain superfamily.
NK (cl17190)
  Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Card14 includes H.sapiens CARD14.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 6 species)
Amniota - vertebrates (1 transcript, 1 species)

 

 

 

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