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HomoloGene:2522. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   UMOD,  H.sapiens
uromodulin
    NP_001265543.1
673 aa
   UMOD,  P.troglodytes
uromodulin
    XP_003954410.1
318 aa
   UMOD,  M.mulatta
uromodulin
    XP_001086040.2
674 aa
   UMOD,  C.lupus
uromodulin
    NP_001003003.1
642 aa
   UMOD,  B.taurus
uromodulin
    NP_776638.1
643 aa
   Umod,  M.musculus
uromodulin
    NP_001265534.1
642 aa
   Umod,  R.norvegicus
uromodulin
    NP_058778.1
644 aa
   LOC100491428,  X.tropicalis
uromodulin-like
    XP_002932031.1
861 aa
   LOC100491925,  X.tropicalis
uromodulin-like
    XP_002932034.2
892 aa
   LOC101731793,  X.tropicalis
uncharacterized LOC101731793
    XP_004918347.1
732 aa
   LOC101731733,  X.tropicalis
uromodulin-like
    XP_004918346.1
282 aa
   LOC100492097,  X.tropicalis
uromodulin-like
    XP_004918349.1
1070 aa
   LOC101732035,  X.tropicalis
uncharacterized LOC101732035
    XP_004918350.1
1217 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hyperuricemic nephropathy, familial juvenile.
Medullary cystic kidney disease 2.
Glomerulocystic kidney disease with hyperuricemia and isosthenuria.



Publications
Articles associated with genes and sequences of this homology group.

Association between genotype and phenotype in uromodulin-associated kidney disease.
Moskowitz JL, et al. Clin J Am Soc Nephrol 8, 1349-57 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
EGF_3 (pfam12947)
  EGF domain.
DDE_4 (pfam13359)
  DDE superfamily endonuclease.
VWA_2 (pfam13519)
  von Willebrand factor type A domain.
RT_like (cl02808)
  RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, ...
EGF_3 (pfam12947)
  EGF domain.
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Zona_pellucida (cl02523)
  Zona pellucida-like domain.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Umod includes H.sapiens UMOD and R.norvegicus Umod.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 9 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

 

 

 

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