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HomoloGene:2122. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PTPN11,  H.sapiens
protein tyrosine phosphatase, non-receptor type 11
    NP_002825.3
593 aa
   PTPN11,  P.troglodytes
protein tyrosine phosphatase, non-receptor type 11
    XP_522535.3
460 aa
   PTPN11,  M.mulatta
protein tyrosine phosphatase, non-receptor type 11
    XP_001110117.1
593 aa
   PTPN11,  C.lupus
protein tyrosine phosphatase, non-receptor type 11
    XP_005636307.1
597 aa
   PTPN11,  B.taurus
protein tyrosine phosphatase, non-receptor type 11
    XP_002694636.2
593 aa
   Ptpn11,  M.musculus
protein tyrosine phosphatase, non-receptor type 11
    NP_035332.1
597 aa
   Ptpn11,  R.norvegicus
protein tyrosine phosphatase, non-receptor type 11
    NP_001171064.1
597 aa
   PTPN11,  G.gallus
protein tyrosine phosphatase, non-receptor type 11
    NP_990299.1
593 aa
   ptpn11a,  D.rerio
protein tyrosine phosphatase, non-receptor type 11, a
    NP_956140.1
594 aa
   csw,  D.melanogaster
corkscrew
    NP_001259174.1
894 aa
   AgaP_AGAP002438,  A.gambiae
AgaP_AGAP002438
    XP_563746.4
643 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Hemizygotes die at the larval-pupal transition; dissected third instar larvae display small imaginal discs. Larval neuroblast cells show low mitotic index, but chromosome morphology appears normal. Homozygous germ-line clones produce inviable embryos with U-shaped or twisted phenotypes, which are unaffected by paternal genotype or developmental temperature.

H.sapiens
Leopard syndrome.
Noonan syndrome 1.
Leukemia, juvenile myelomonocytic.



Publications
Articles associated with genes and sequences of this homology group.

Medulloblastoma in a patient with the PTPN11 p.Thr468Met mutation.
Rankin J, et al. Am J Med Genet A 161A, 2027-9 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PTPc (smart00194)
  Protein tyrosine phosphatase, catalytic domain.
PTPc (cd00047)
  Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
SH2 (cl15255)
  Src homology 2 (SH2) domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ptpn11 includes H.sapiens PTPN11 and R.norvegicus Ptpn11.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (15 transcripts, 9 species)
Mammalia - mammals (13 transcripts, 10 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (12 transcripts, 9 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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