Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:465. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   VHL,  H.sapiens
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
    NP_000542.1
213 aa
   LOC701870,  M.mulatta
von Hippel-Lindau disease tumor suppressor-like
    XP_001090152.2
101 aa
   VHL,  C.lupus
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
    NP_001008552.1
219 aa
   VHL,  B.taurus
von Hippel-Lindau tumor suppressor
    NP_001103489.1
193 aa
   Vhl,  M.musculus
von Hippel-Lindau tumor suppressor
    NP_033533.1
181 aa
   Vhl,  R.norvegicus
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
    NP_434688.1
185 aa
   VHL,  G.gallus
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
    XP_414447.3
185 aa
   vhl,  X.tropicalis
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
    NP_001016367.1
167 aa
   vhl,  D.rerio
von Hippel-Lindau tumor suppressor
    NP_001074153.1
175 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Renal cell carcinoma, somatic.
Pheochromocytoma.
von Hippel-Lindau syndrome.
Polycythemia, benign familial.
Hemangioblastoma, cerebellar, somatic.



Publications
Articles associated with genes and sequences of this homology group.

Tubular von Hippel-Lindau knockout protects against rhabdomyolysis-induced AKI.
Fähling M, et al. J Am Soc Nephrol 24, 1806-19 (2013).
VHL gene alterations in Italian patients with isolated renal cell carcinomas.
Muscarella LA, et al. Int J Biol Markers 28, 208-15 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Trypan_PARP (pfam05887)
  Procyclic acidic repetitive protein (PARP).
pVHL (cl03381)
  von Hippel-Landau (pVHL) tumor suppressor protein.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Vhl includes H.sapiens VHL and R.norvegicus Vhl.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 10 species)
Actinopterygii - bony fishes (6 transcripts, 6 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

 

 

 

Write to the Help Desk