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HomoloGene:465. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   VHL,  H.sapiens
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
213 aa
   LOC701870,  M.mulatta
von Hippel-Lindau disease tumor suppressor-like
101 aa
   VHL,  C.lupus
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
219 aa
   VHL,  B.taurus
von Hippel-Lindau tumor suppressor
193 aa
   Vhl,  M.musculus
von Hippel-Lindau tumor suppressor
181 aa
   Vhl,  R.norvegicus
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
185 aa
   VHL,  G.gallus
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
185 aa
   vhl,  X.tropicalis
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
167 aa
   vhl,  D.rerio
von Hippel-Lindau tumor suppressor
175 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Renal cell carcinoma, somatic.
von Hippel-Lindau syndrome.
Polycythemia, benign familial.
Hemangioblastoma, cerebellar, somatic.

Articles associated with genes and sequences of this homology group.

Tubular von Hippel-Lindau knockout protects against rhabdomyolysis-induced AKI.
Fähling M, et al. J Am Soc Nephrol 24, 1806-19 (2013).
VHL gene alterations in Italian patients with isolated renal cell carcinomas.
Muscarella LA, et al. Int J Biol Markers 28, 208-15 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Trypan_PARP (pfam05887)
  Procyclic acidic repetitive protein (PARP).
pVHL (cl03381)
  von Hippel-Landau (pVHL) tumor suppressor protein.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Vhl includes H.sapiens VHL and R.norvegicus Vhl.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (11 transcripts, 10 species)
Actinopterygii - bony fishes (6 transcripts, 6 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)




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