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HomoloGene:2207. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ROS1,  H.sapiens
c-ros oncogene 1 , receptor tyrosine kinase
    NP_002935.2
2347 aa
   ROS1,  P.troglodytes
c-ros oncogene 1 , receptor tyrosine kinase
    XP_527487.2
2347 aa
   ROS1,  M.mulatta
c-ros oncogene 1 , receptor tyrosine kinase
    XP_001110859.2
2346 aa
   ROS1,  C.lupus
c-ros oncogene 1 , receptor tyrosine kinase
    XP_541215.4
2349 aa
   ROS1,  B.taurus
c-ros oncogene 1 , receptor tyrosine kinase
    XP_003586512.2
2352 aa
   Ros1,  M.musculus
Ros1 proto-oncogene
    NP_035412.2
2340 aa
   Ros1,  R.norvegicus
c-ros oncogene 1 , receptor tyrosine kinase
    NP_037006.1
2338 aa
   ROS1,  G.gallus
c-ros oncogene 1 , receptor tyrosine kinase
    NP_990588.2
2311 aa
   ros1,  X.tropicalis
c-ros oncogene 1 , receptor tyrosine kinase
    XP_004914923.1
2311 aa
   ros1,  D.rerio
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)
    XP_694329.6
1442 aa
   sev,  D.melanogaster
sevenless
    NP_511114.2
2554 aa
   AgaP_AGAP000015,  A.gambiae
AgaP_AGAP000015
    XP_566417.4
2447 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Homozygotes and hemizygotes lack the R7 rhabdomere in all ommatidia; the R7 photoreceptor cell instead develops as an accessory lens-secreting cell, the equatorial cone cell (Tomlinson and Ready, 1986; Tomlinson and Ready, 1987). Cell autonomous in mosaics (Harris, Stark and Walker, 1976). Mosaic analysis demonstrates that sev+ product is required only in the presumptive photoreceptor 7 cell and is therefore involved in receiving signals from neighboring cells. Electroretinograms normal; defective in response to ultraviolet; in T-maze tests sev flies prefer visible to ultraviolet wavelengths and green light to darkness; slight preference for blue wavelengths over ultraviolet used in selecting mutant alleles (Gerresheim, 1988). (See FlyBase for complete description.)



Publications
Articles associated with genes and sequences of this homology group.

Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins.
Davare MA, et al. Proc Natl Acad Sci U S A 110, 19519-24 (2013).
Molecular pathways: ROS1 fusion proteins in cancer.
Davies KD & Doebele RC. Clin Cancer Res 19, 4040-5 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
LY (smart00135)
  Low-density lipoprotein-receptor YWTD domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ros1 includes H.sapiens ROS1 and R.norvegicus Ros1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (4 transcripts, 4 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

 

 

 

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