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HomoloGene:20739. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CXCR4,  H.sapiens
chemokine (C-X-C motif) receptor 4
    NP_003458.1
352 aa
   CXCR4,  P.troglodytes
chemokine (C-X-C motif) receptor 4
    NP_001009047.1
352 aa
   CXCR4,  M.mulatta
chemokine (C-X-C motif) receptor 4
    NP_001036110.1
352 aa
   CXCR4,  C.lupus
chemokine (C-X-C motif) receptor 4
    NP_001041491.1
353 aa
   CXCR4,  B.taurus
chemokine (C-X-C motif) receptor 4
    NP_776726.1
353 aa
   Cxcr4,  M.musculus
chemokine (C-X-C motif) receptor 4
    NP_034041.2
359 aa
   Cxcr4,  R.norvegicus
chemokine (C-X-C motif) receptor 4
    NP_071541.2
349 aa
   CXCR4,  G.gallus
chemokine (C-X-C motif) receptor 4
    NP_989948.2
362 aa
   cxcr4,  X.tropicalis
chemokine (C-X-C motif) receptor 4
    NP_001090831.1
358 aa
   cxcr4a,  D.rerio
chemokine (C-X-C motif) receptor 4a
    NP_571957.2
360 aa
   cxcr4b,  D.rerio
chemokine (C-X-C motif), receptor 4b
    NP_571909.1
353 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Myelokathexis, isolated.
WHIM syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Aberrant expression of CXCR4 and β-catenin in pancreatic cancer.
Wang Z, et al. Anticancer Res 33, 4103-10 (2013).
Bioinformatics analysis of breast cancer bone metastasis related gene-CXCR4.
Zhang HW, et al. Asian Pac J Trop Med 6, 732-8 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CXCR4_N (pfam12109)
  CXCR4 Chemokine receptor N terminal.
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).
PHA03087 (PHA03087)
  G protein-coupled chemokine receptor-like protein; Provisional.
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cxcr4 includes H.sapiens CXCR4 and R.norvegicus Cxcr4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 14 species)
Actinopterygii - bony fishes (12 transcripts, 8 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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