Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:3922. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MYCN,  H.sapiens
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
    NP_005369.2
464 aa
   MYCN,  P.troglodytes
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
    XP_001162405.1
464 aa
   MYCN,  M.mulatta
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
    XP_001091369.2
555 aa
   MYCN,  C.lupus
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
    XP_005630203.1
208 aa
   MYCN,  B.taurus
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
    XP_002691569.1
278 aa
   Mycn,  M.musculus
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
    NP_032735.3
462 aa
   Mycn,  R.norvegicus
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
    NP_001013114.1
462 aa
   MYCN,  G.gallus
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived
    NP_001026262.1
441 aa
   mycn,  X.tropicalis
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
    NP_001006874.1
445 aa
   mycn,  D.rerio
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
    NP_997779.1
455 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Feingold syndrome.
Microcephaly and digital abnormalities with normal intelligence.



Publications
Articles associated with genes and sequences of this homology group.

Targeting MYCN in neuroblastoma by BET bromodomain inhibition.
Puissant A, et al. Cancer Discov 3, 308-23 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Myc_N (pfam01056)
  Myc amino-terminal region.
Myc_N (pfam01056)
  Myc amino-terminal region.
HLH (cl00081)
  Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mycn includes H.sapiens MYCN and R.norvegicus Mycn.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 6 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

 

 

 

Write to the Help Desk