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HomoloGene:3600. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NLRP3,  H.sapiens
NLR family, pyrin domain containing 3
    NP_004886.3
1036 aa
   NLRP3,  P.troglodytes
NLR family, pyrin domain containing 3
    XP_003949788.1
1036 aa
   NLRP3,  M.mulatta
NLR family, pyrin domain containing 3
    NP_001107823.1
1035 aa
   NLRP3,  C.lupus
NLR family, pyrin domain containing 3
    XP_848377.2
1065 aa
   NLRP3,  B.taurus
NLR family, pyrin domain containing 3
    NP_001095689.1
1031 aa
   Nlrp3,  M.musculus
NLR family, pyrin domain containing 3
    NP_665826.1
1033 aa
   Nlrp3,  R.norvegicus
NLR family, pyrin domain containing 3
    NP_001178571.1
1035 aa
   NLRP3,  G.gallus
NLR family, pyrin domain containing 3
    XP_001233262.3
975 aa
   LOC100497524,  X.tropicalis
NACHT, LRR and PYD domains-containing protein 3-like
    XP_002945565.2
883 aa
   LOC100486578,  X.tropicalis
NACHT, LRR and PYD domains-containing protein 12-like
    XP_002937317.2
935 aa
   LOC101731251,  X.tropicalis
protein NLRC3-like
    XP_004911151.1
881 aa
   LOC100487412,  X.tropicalis
protein NLRC3-like
    XP_002938247.2
940 aa
   LOC100491706,  X.tropicalis
NACHT, LRR and PYD domains-containing protein 14-like
    XP_002944439.2
885 aa
   LOC101730480,  X.tropicalis
NACHT, LRR and PYD domains-containing protein 3-like
    XP_004917655.1
677 aa
   LOC100495083,  X.tropicalis
NACHT, LRR and PYD domains-containing protein 3-like
    XP_002940532.2
895 aa
   LOC100493406,  X.tropicalis
NACHT, LRR and PYD domains-containing protein 12-like
    XP_004917630.1
880 aa
   LOC100486737,  X.tropicalis
NACHT, LRR and PYD domains-containing protein 3-like
    XP_002937318.2
881 aa
   LOC101730955,  X.tropicalis
NACHT, LRR and PYD domains-containing protein 12-like
    XP_004917628.1
880 aa
   LOC101730849,  X.tropicalis
NACHT, LRR and PYD domains-containing protein 3-like
    XP_004917660.1
678 aa
   LOC100488969,  X.tropicalis
NACHT, LRR and PYD domains-containing protein 9-like
    XP_002943172.2
189 aa
   LOC100488807,  X.tropicalis
NACHT, LRR and PYD domains-containing protein 14-like
    XP_002943171.1
235 aa
   LOC100489137,  X.tropicalis
protein NLRC5-like
    XP_002943173.1
187 aa
   LOC100488643,  X.tropicalis
NACHT, LRR and PYD domains-containing protein 4-like
    XP_002943170.2
567 aa
   LOC101730774,  X.tropicalis
NACHT, LRR and PYD domains-containing protein 1-like
    XP_004917659.1
172 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cold-induced autoinflammatory syndrome, familial.
Muckle-Wells syndrome.
CINCA syndrome.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Pyrin_NALPs (cd08320)
  Pyrin death domain found in NALP proteins.
LRR_RI (smart00368)
  Leucine rich repeat, ribonuclease inhibitor type.
AAA (smart00382)
  ATPases associated with a variety of cellular activities.
NACHT (pfam05729)
  NACHT domain.
COG4886 (COG4886)
  Leucine-rich repeat (LRR) protein [Function unknown].
LRR_RI (cd00116)
  Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
DD_superfamily (cl14633)
  The Death Domain Superfamily of protein-protein interaction domains.
LRR_RI (cl15309)
  Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
AdkA (cl17890)
  Archaeal adenylate kinase [Nucleotide transport and metabolism].
LRR_8 (pfam13855)
  Leucine rich repeat.
FISNA (pfam14484)
  Fish-specific NACHT associated domain.
DD (cl14633)
  Death Domain Superfamily of protein-protein interaction domains.
AAA (cl18944)
  The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nlrp3 includes H.sapiens NLRP3 and R.norvegicus Nlrp3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 7 species)

 

 

 

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