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HomoloGene:56584. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GPSM2,  H.sapiens
G-protein signaling modulator 2
    NP_037428.3
684 aa
   GPSM2,  P.troglodytes
G-protein signaling modulator 2
    XP_001146355.2
684 aa
   GPSM2,  M.mulatta
G-protein signaling modulator 2
    XP_002801724.1
608 aa
   GPSM2,  C.lupus
G-protein signaling modulator 2
    XP_547248.3
685 aa
   GPSM2,  B.taurus
G-protein signaling modulator 2
    NP_001179284.1
681 aa
   Gpsm2,  M.musculus
G-protein signalling modulator 2 (AGS3-like, C. elegans)
    NP_083798.2
679 aa
   Gpsm2,  R.norvegicus
G-protein signaling modulator 2
    NP_001178891.1
678 aa
   GPSM2,  G.gallus
G-protein signaling modulator 2
    XP_004943149.1
659 aa
   gpsm2,  X.tropicalis
G-protein signaling modulator 2
    XP_002932195.2
663 aa
   gpsm2,  D.rerio
G-protein signalling modulator 2 (AGS3-like, C. elegans)
    NP_956732.1
649 aa
   raps,  D.melanogaster
rapsynoid
    NP_524999.2
658 aa
   AgaP_AGAP008977,  A.gambiae
AgaP_AGAP008977
    XP_319728.4
631 aa
   ags-3,  C.elegans
ags-3
    NP_741788.1
589 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Deafness, autosomal recessive 82.



Publications
Articles associated with genes and sequences of this homology group.

GPSM2 mutations in Chudley-McCullough syndrome.
Diaz-Horta O, et al. Am J Med Genet A 158A, 2972-3 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
GoLoco (pfam02188)
  GoLoco motif.
TPR_12 (pfam13424)
  Tetratricopeptide repeat.
TPR (cd00189)
  Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
TPR (cl02429)
  Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
TPR_12 (pfam13424)
  Tetratricopeptide repeat.
GoLoco (cl12112)
  GEF specific for Galpha_i proteins



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gpsm2 includes H.sapiens GPSM2 and R.norvegicus Gpsm2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 14 species)
Actinopterygii - bony fishes (13 transcripts, 7 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 6 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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