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HomoloGene:68387. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ALK,  H.sapiens
anaplastic lymphoma receptor tyrosine kinase
    NP_004295.2
1620 aa
   ALK,  P.troglodytes
anaplastic lymphoma receptor tyrosine kinase
    XP_003309006.2
1663 aa
   ALK,  C.lupus
anaplastic lymphoma receptor tyrosine kinase
    XP_540136.3
1631 aa
   LOC536642,  B.taurus
ALK tyrosine kinase receptor-like
    XP_002691538.2
1238 aa
   Alk,  M.musculus
anaplastic lymphoma kinase
    NP_031465.2
1621 aa
   Alk,  R.norvegicus
anaplastic lymphoma receptor tyrosine kinase
    NP_001162572.1
1617 aa
   ALK,  G.gallus
anaplastic lymphoma receptor tyrosine kinase
    XP_004940244.1
1375 aa
   LOC100495071,  X.tropicalis
ALK tyrosine kinase receptor-like
    XP_002938468.2
1532 aa
   alk,  D.rerio
anaplastic lymphoma kinase (Ki-1)
    XP_691964.5
1148 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Neuroblastoma, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology.
Hallberg B & Palmer RH. Nat Rev Cancer 13, 685-700 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MAM (cd06263)
  Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
Gly_rich (pfam12810)
  Glycine rich protein.
LDLa (cl00104)
  Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
MAM (cl02479)
  Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
MAM (pfam00629)
  MAM domain.
LDLa (cl00104)
  Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Alk includes H.sapiens ALK.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (5 transcripts, 5 species)
Amphibia - amphibians (3 transcripts, 1 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (4 transcripts, 3 species)

 

 

 

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