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HomoloGene:55455. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   RPGR,  H.sapiens
retinitis pigmentosa GTPase regulator
    NP_000319.1
815 aa
   RPGR,  P.troglodytes
X-linked retinitis pigmentosa GTPase regulator-like
    XP_003954016.1
476 aa
   RPGR,  C.lupus
retinitis pigmentosa GTPase regulator
    NP_001003126.1
1003 aa
   Rpgr,  M.musculus
retinitis pigmentosa GTPase regulator
    NP_001171421.1
1039 aa
   Rpgr,  R.norvegicus
retinitis pigmentosa GTPase regulator
    XP_006256751.1
542 aa
   rpgr,  X.tropicalis
retinitis pigmentosa GTPase regulator
    NP_001037872.1
729 aa
   rpgrb,  D.rerio
retinitis pigmentosa GTPase regulator b
    XP_005169406.1
678 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cone-rod dystrophy.
Retinitis pigmentosa-3.
Retinitis pigmentosa, X-linked with deafness and sinorespiratory infections.
Retinitis pigmentosa, X-linked, with recurrent respiratory infections.
Cone dystrophy-1.
Macular degeneration, X-linked atrophic.



Publications
Articles associated with genes and sequences of this homology group.

RPGR mutations might cause reduced orientation of respiratory cilia.
Bukowy-Bieryłło Z, et al. Pediatr Pulmonol 48, 352-63 (2013).
Functional characterization of the human RPGR proximal promoter.
Shu X, et al. Invest Ophthalmol Vis Sci 53, 3951-8 (2012).
The role of RPGR in cilia formation and actin stability.
Gakovic M, et al. Hum Mol Genet 20, 4840-50 (2011).
Clinical course of cone dystrophy caused by mutations in the RPGR gene.
Thiadens AA, et al. Graefes Arch Clin Exp Ophthalmol 249, 1527-35 (2011).
Novel RPGR-ORF15 mutations in X-linked retinitis pigmentosa patients.
Gan DK, et al. Neurosci Lett 500, 16-9 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
RCC1 (pfam00415)
  Regulator of chromosome condensation (RCC1) repeat.
RCC1_2 (pfam13540)
  Regulator of chromosome condensation (RCC1) repeat.
RCC1 (pfam00415)
  Regulator of chromosome condensation (RCC1) repeat.
Adeno_terminal (pfam02459)
  Adenoviral DNA terminal protein.
RCC1_2 (pfam13540)
  Regulator of chromosome condensation (RCC1) repeat.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rpgr includes H.sapiens RPGR.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 9 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (2 transcripts, 1 species)

 

 

 

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