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HomoloGene:55632. Gene conserved in Euarchontoglires Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CFHR1,  H.sapiens
complement factor H-related 1
    NP_002104.2
330 aa
   CFHR1,  P.troglodytes
complement factor H-related 1
    XP_001136846.2
202 aa
   Cfhr1,  M.musculus
complement factor H-related 1
    NP_056595.1
343 aa
   Cfhr1,  R.norvegicus
complement factor H-related 1
    NP_001037692.1
274 aa
   LOC102554977,  R.norvegicus
complement factor H-related protein 1-like
    XP_006250014.1
333 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hemolytic uremic syndrome, atypical, susceptibility to.
Macular degeneration, age-related, reduced risk of.



Publications
Articles associated with genes and sequences of this homology group.

Relevance of complement factor H-related 1 (CFHR1) genotypes in age-related macular degeneration.
MartĂ­nez-Barricarte R, et al. Invest Ophthalmol Vis Sci 53, 1087-94 (2012).
The factor H protein family.
Zipfel PF, et al. Immunopharmacology 42, 53-60 (1999).
Complement factor H: a biomarker for progression of cutaneous squamous cell carcinoma.
Riihilä PM, et al. J Invest Dermatol 134, 498-506 (2014).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CCP (cl00043)
  SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cfhr1 includes H.sapiens CFHR1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (3 transcripts, 3 species)

 

 

 

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