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HomoloGene:223. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PTCH1,  H.sapiens
patched 1
    NP_000255.2
1447 aa
   PTCH1,  P.troglodytes
patched 1
    XP_003312241.1
1526 aa
   PTCH1,  M.mulatta
patched 1
    XP_001111868.2
1551 aa
   PTCH1,  C.lupus
patched 1
    XP_003638919.1
1450 aa
   PTCH1,  B.taurus
patched 1
    NP_001192808.1
1453 aa
   Ptch1,  M.musculus
patched homolog 1
    NP_032983.1
1434 aa
   Ptch1,  R.norvegicus
patched 1
    NP_446018.1
1434 aa
   PTCH1,  G.gallus
patched 1
    NP_990291.1
1442 aa
   ptch1,  X.tropicalis
patched 1
    XP_002935019.2
1436 aa
   ptch1,  D.rerio
patched 1
    XP_001922161.4
1243 aa
   ptc,  D.melanogaster
patched
    NP_523661.2
1286 aa
   AgaP_AGAP011395,  A.gambiae
AgaP_AGAP011395
    XP_317925.4
1241 aa
   ptc-1,  C.elegans
ptc-1
    NP_495662.2
1408 aa
   ptc-3,  C.elegans
ptc-3
    NP_494384.2
1358 aa
   ptc-2,  C.elegans
ptc-2
    NP_495218.2
667 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
The ptc gene is involved in patterning within segments in Drosophila. The viable first-identified mutant has a small tuft of hairs between eyes and antennae and shows basal twinning of the anterior halves of wings; it overlaps wild type. ptc/Tp(2;3)dp has an extreme form of this mutant phenotype. Other mutants are embryonic lethals of the segment-polarity type. There is a mirror-image duplication of segment boundaries and adjacent cuticle of all segments with deletion of the remainder of the segment. (See FlyBase for complete description.)

H.sapiens
Basal cell nevus syndrome.
Medulloblastoma, somatic.
Basal cell carcinoma, somatic.
Holoprosencephaly-7.



Publications
Articles associated with genes and sequences of this homology group.

Engineered knottin peptide enables noninvasive optical imaging of intracranial medulloblastoma.
Moore SJ, et al. Proc Natl Acad Sci U S A 110, 14598-603 (2013).
Inhibition of patched-1 prevents injury-induced neointimal hyperplasia.
Redmond EM, et al. Arterioscler Thromb Vasc Biol 33, 1960-4 (2013).
Association between PTCH1 polymorphisms and risk of neural tube defects in a Chinese population.
Wang Z, et al. Birth Defects Res A Clin Mol Teratol 97, 409-15 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Sterol-sensing (pfam12349)
  Sterol-sensing domain of SREBP cleavage-activation.
SecD_SecF (cl14618)
  Protein export membrane protein.
7TM-7TMR_HD (pfam07698)
  7TM receptor with intracellular HD hydrolase.
Sterol-sensing (pfam12349)
  Sterol-sensing domain of SREBP cleavage-activation.
Thg1C (pfam14413)
  Thg1 C terminal domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ptch1 includes H.sapiens PTCH1 and R.norvegicus Ptch1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 10 species)
Actinopterygii - bony fishes (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (6 transcripts, 2 species)

Arthropoda
Insecta - insects (5 transcripts, 4 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

 

 

 

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