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HomoloGene:4049. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   IRS1,  H.sapiens
insulin receptor substrate 1
    NP_005535.1
1242 aa
   IRS1,  P.troglodytes
insulin receptor substrate 1
    XP_001134895.1
1241 aa
   IRS1,  C.lupus
insulin receptor substrate 1
    XP_543274.3
1240 aa
   IRS1,  B.taurus
insulin receptor substrate 1
    XP_003585821.1
1237 aa
   Irs1,  M.musculus
insulin receptor substrate 1
    NP_034700.2
1231 aa
   Irs1,  R.norvegicus
insulin receptor substrate 1
    NP_037101.1
1235 aa
   IRS1,  G.gallus
insulin receptor substrate 1
    XP_004951158.1
1024 aa
   LOC100495320,  X.tropicalis
insulin receptor substrate 1-B-like
    XP_004914519.1
1120 aa
   irs1,  D.rerio
insulin receptor substrate 1
    XP_005157831.1
1119 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Diabetes mellitus, noninsulin-dependent.
Coronary artery disease, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

The IRS1 rs2943641 variant and risk of future cancer among morbidly obese individuals.
Maglio C, et al. J Clin Endocrinol Metab 98, E785-9 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Irs1 includes H.sapiens IRS1 and R.norvegicus Irs1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 9 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

 

 

 

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