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HomoloGene:1065. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   DUSP4,  H.sapiens
dual specificity phosphatase 4
    NP_001385.1
394 aa
   DUSP4,  P.troglodytes
dual specificity phosphatase 4
    XP_520046.2
394 aa
   DUSP4,  M.mulatta
dual specificity phosphatase 4
    XP_001110903.1
394 aa
   LOC482880,  C.lupus
dual specificity protein phosphatase 4-like
    XP_539995.3
394 aa
   DUSP4,  B.taurus
dual specificity phosphatase 4
    NP_001193882.1
394 aa
   Dusp4,  M.musculus
dual specificity phosphatase 4
    NP_795907.1
398 aa
   Dusp4,  R.norvegicus
dual specificity phosphatase 4
    NP_071535.1
395 aa
   DUSP4,  G.gallus
dual specificity phosphatase 4
    NP_990169.1
375 aa
   dusp4,  X.tropicalis
dual specificity phosphatase 4
    NP_001016109.1
388 aa
   dusp4,  D.rerio
dual specificity phosphatase 4
    NP_957465.1
367 aa
   IBR5,  A.thaliana
IBR5
    NP_178534.2
257 aa
   Os06g0308100,  O.sativa
Os06g0308100
    NP_001057473.1
279 aa
   Os02g0720300,  O.sativa
Os02g0720300
    NP_001047951.1
268 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Mitogen-activated protein kinase phosphatase 2, MKP-2, regulates early inflammation in acute lung injury.
Cornell TT, et al. Am J Physiol Lung Cell Mol Physiol 303, L251-8 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DSPc (cl00053)
  Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
RHOD (cl00125)
  Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dusp4 includes H.sapiens DUSP4 and R.norvegicus Dusp4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (27 transcripts, 21 species)
Liliopsida - monocots (17 transcripts, 8 species)
Bryopsida - mosses (2 transcripts, 1 species)
Coniferopsida - conifers (2 transcripts, 2 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Chordata
Mammalia - mammals (8 transcripts, 7 species)
Actinopterygii - bony fishes (8 transcripts, 7 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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