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HomoloGene:49590. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PRKAA1,  H.sapiens
protein kinase, AMP-activated, alpha 1 catalytic subunit
    NP_996790.3
574 aa
   PRKAA1,  P.troglodytes
protein kinase, AMP-activated, alpha 1 catalytic subunit
    XP_003310787.1
574 aa
   PRKAA1,  M.mulatta
protein kinase, AMP-activated, alpha 1 catalytic subunit
    XP_001086285.1
574 aa
   PRKAA1,  C.lupus
protein kinase, AMP-activated, alpha 1 catalytic subunit
    XP_536491.4
587 aa
   PRKAA1,  B.taurus
protein kinase, AMP-activated, alpha 1 catalytic subunit
    NP_001103272.1
458 aa
   Prkaa1,  M.musculus
protein kinase, AMP-activated, alpha 1 catalytic subunit
    NP_001013385.3
559 aa
   Prkaa1,  R.norvegicus
protein kinase, AMP-activated, alpha 1 catalytic subunit
    NP_062015.2
559 aa
   PRKAA1,  G.gallus
protein kinase, AMP-activated, alpha 1 catalytic subunit
    NP_001034692.1
560 aa
   prkaa1,  X.tropicalis
protein kinase, AMP-activated, alpha 1 catalytic subunit
    NP_001120434.1
551 aa
   prkaa1,  D.rerio
protein kinase, AMP-activated, alpha 1 catalytic subunit
    NP_001103756.1
573 aa
   KIN10,  A.thaliana
KIN10
    NP_566130.1
512 aa
   KIN11,  A.thaliana
KIN11
    NP_566843.1
512 aa
   Os05g0530500,  O.sativa
Os05g0530500
    NP_001056128.1
503 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Metformin-stimulated AMPK-α1 promotes microvascular repair in acute lung injury.
Jian MY, et al. Am J Physiol Lung Cell Mol Physiol 305, L844-55 (2013).
AMPKα1-sensitivity of Orai1 and Ca(2+) entry in T - lymphocytes.
Bhavsar SK, et al. Cell Physiol Biochem 32, 687-98 (2013).
Stilbene analogs of resveratrol improve insulin resistance through activation of AMPK.
Ito-Nagahata T, et al. Biosci Biotechnol Biochem 77, 1229-35 (2013).
CMV infected or not CMV infected: that is the question.
Emery VC. Eur J Immunol 43, 886-8 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
S_TKc (smart00220)
  Serine/Threonine protein kinases, catalytic domain.
AMPKA_C_like (cl17070)
  C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains.
UBA (cl00153)
  Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been suggested that UBA domains are involved in conferring protein target specificity. The domain, a compact three helix bundle, has a conserved GFP-loop and the proline is thought to be critical for binding. The UBA domain is distinct from the conserved three helical domain seen in the N-terminus of EF-TS and eukaryotic NAC proteins.
AMPKA_C_like (cl17070)
  C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Prkaa1 includes H.sapiens PRKAA1 and R.norvegicus Prkaa1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (78 transcripts, 32 species)
Liliopsida - monocots (25 transcripts, 9 species)
Coniferopsida - conifers (4 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)

Chordata
Mammalia - mammals (24 transcripts, 13 species)
Actinopterygii - bony fishes (24 transcripts, 7 species)
Ascidiacea - tunicates (7 transcripts, 2 species)
Amphibia - amphibians (5 transcripts, 2 species)
Aves - birds (4 transcripts, 3 species)
Amniota - vertebrates (3 transcripts, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (4 transcripts, 3 species)
Arachnida - arachnids (1 transcript, 1 species)

Porifera
Demospongiae - sponges (3 transcripts, 1 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)
Polychaeta - segmented worms (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (8 transcripts, 1 species)

Oomycetes
Pythiales - oomycetes (2 transcripts, 1 species)
Peronosporales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (3 transcripts, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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