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HomoloGene:158. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   HMBS,  H.sapiens
hydroxymethylbilane synthase
    NP_000181.2
361 aa
   HMBS,  M.mulatta
hydroxymethylbilane synthase
    XP_001101764.1
391 aa
   HMBS,  C.lupus
hydroxymethylbilane synthase
    XP_546491.2
361 aa
   HMBS,  B.taurus
hydroxymethylbilane synthase
    NP_001039672.1
361 aa
   Hmbs,  M.musculus
hydroxymethylbilane synthase
    NP_038579.2
361 aa
   Hmbs,  R.norvegicus
hydroxymethylbilane synthase
    NP_037300.2
361 aa
   HMBS,  G.gallus
hydroxymethylbilane synthase
    XP_417846.2
358 aa
   hmbs,  X.tropicalis
hydroxymethylbilane synthase
    NP_001005635.1
351 aa
   hmbsa,  D.rerio
hydroxymethylbilane synthase a
    NP_957448.1
358 aa
   hmbsb,  D.rerio
hydroxymethylbilane synthase, b
    NP_001019559.1
360 aa
   l(3)02640,  D.melanogaster
lethal (3) 02640
    NP_612103.1
652 aa
   AgaP_AGAP011080,  A.gambiae
AgaP_AGAP011080
    XP_564464.3
599 aa
   HEM3,  S.cerevisiae
HEM3
    NP_010076.1
327 aa
   KLLA0C15147g,  K.lactis
KLLA0C15147g
    XP_452879.1
327 aa
   AGOS_ABL107C,  E.gossypii
AGOS_ABL107C
    NP_982840.1
326 aa
   hem3,  S.pombe
hem3
    NP_001018179.1
336 aa
   MGG_04860,  M.oryzae
MGG_04860
    XP_003712340.1
340 aa
   NCU10292,  N.crassa
NCU10292
    XP_001728039.1
337 aa
   HEMC,  A.thaliana
HEMC
    NP_196445.1
382 aa
   Os02g0168800,  O.sativa
Os02g0168800
    NP_001046017.1
358 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Porphyria, acute intermittent.
Porphyria, acute intermittent, nonerythroid variant.



Publications
Articles associated with genes and sequences of this homology group.

Acute Intermittent Porphyria
Whatley SD, et al. (1993).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PLN02691 (PLN02691)
  porphobilinogen deaminase.
hemC (PRK00072)
  porphobilinogen deaminase; Reviewed.
HMBS (cd00494)
  Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hmbs includes H.sapiens HMBS and R.norvegicus Hmbs.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (47 transcripts, 26 species)
Liliopsida - monocots (11 transcripts, 9 species)
Coniferopsida - conifers (4 transcripts, 3 species)
Bryopsida - mosses (3 transcripts, 1 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Chordata
Mammalia - mammals (15 transcripts, 12 species)
Actinopterygii - bony fishes (12 transcripts, 7 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (9 transcripts, 9 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (4 transcripts, 1 species)
Trematoda - flatworms (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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