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HomoloGene:20283. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SLC12A2,  H.sapiens
solute carrier family 12 (sodium/potassium/chloride transporter), member 2
    NP_001243390.1
1196 aa
   SLC12A2,  P.troglodytes
solute carrier family 12 (sodium/potassium/chloride transporters), member 2
    XP_003310846.1
1195 aa
   SLC12A2,  M.mulatta
solute carrier family 12 (sodium/potassium/chloride transporters), member 2
    XP_001098624.1
1210 aa
   SLC12A2,  C.lupus
solute carrier family 12 (sodium/potassium/chloride transporter), member 2
    XP_538611.5
995 aa
   SLC12A2,  B.taurus
solute carrier family 12 (sodium/potassium/chloride transporters), member 2
    NP_777207.1
1201 aa
   Slc12a2,  M.musculus
solute carrier family 12, member 2
    NP_033220.2
1206 aa
   Slc12a2,  R.norvegicus
solute carrier family 12 (sodium/potassium/chloride transporter), member 2
    NP_113986.1
1203 aa
   SLC12A2,  G.gallus
solute carrier family 12 (sodium/potassium/chloride transporters), member 2
    XP_004949435.1
1134 aa
   slc12a2,  X.tropicalis
solute carrier family 12 (sodium/potassium/chloride transporter), member 2
    XP_004910531.1
1161 aa
   slc12a2,  D.rerio
solute carrier family 12 (potassium/chloride transporters), member 2
    NP_001002080.1
1136 aa
   Ncc69,  D.melanogaster
sodium chloride cotransporter 69
    NP_648572.1
1171 aa
   AgaP_AGAP001557,  A.gambiae
AgaP_AGAP001557
    XP_321556.3
1127 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The Drosophila NKCC Ncc69 is required for normal renal tubule function.
Rodan AR, et al. Am J Physiol Cell Physiol 303, C883-94 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
AA_permease (pfam00324)
  Amino acid permease.
AA_permease_N (pfam08403)
  Amino acid permease N-terminal.
2a30 (TIGR00930)
  K-Cl cotransporter.
AA_permease_N (pfam08403)
  Amino acid permease N-terminal.
Polysacc_synt_C (cl10513)
  Polysaccharide biosynthesis C-terminal domain.
Aa_trans (cl17468)
  Transmembrane amino acid transporter protein.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Slc12a2 includes H.sapiens SLC12A2 and R.norvegicus Slc12a2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (18 transcripts, 9 species)
Mammalia - mammals (13 transcripts, 12 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (9 transcripts, 8 species)
Branchiopoda - crustaceans (4 transcripts, 1 species)
Arachnida - arachnids (2 transcripts, 2 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)

 

 

 

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