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HomoloGene:23771. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MEGF10,  H.sapiens
multiple EGF-like-domains 10
    NP_115822.1
1140 aa
   MEGF10,  P.troglodytes
multiple EGF-like-domains 10
    XP_517907.2
1140 aa
   MEGF10,  M.mulatta
multiple EGF-like-domains 10
    XP_001097941.1
1137 aa
   MEGF10,  C.lupus
multiple EGF-like-domains 10
    XP_005626533.1
1137 aa
   MEGF10,  B.taurus
multiple EGF-like-domains 10
    NP_001039916.2
1136 aa
   Megf10,  M.musculus
multiple EGF-like-domains 10
    NP_001001979.1
1147 aa
   Megf10,  R.norvegicus
multiple EGF-like domains 10
    NP_001094127.1
1145 aa
   MEGF10,  G.gallus
multiple EGF-like-domains 10
    XP_424719.3
1130 aa
   megf10,  X.tropicalis
multiple EGF-like-domains 10
    NP_001072726.1
1114 aa
   megf10,  D.rerio
multiple EGF-like-domains 10
    XP_001922524.2
1120 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
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Publications
Articles associated with genes and sequences of this homology group.

MEGF10 association with schizophrenia.
Chen X, et al. Biol Psychiatry 63, 441-8 (2008).
Megf10 regulates the progression of the satellite cell myogenic program.
Holterman CE, et al. J Cell Biol 179, 911-22 (2007).
MEGF10 functions as a receptor for the uptake of amyloid-β.
Singh TD, et al. FEBS Lett 584, 3936-42 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
EMI (pfam07546)
  EMI domain.
Laminin_EGF (pfam00053)
  Laminin EGF-like (Domains III and V).
EMI (pfam07546)
  EMI domain.
EGF_Lam (cl19065)
  Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Megf10 includes H.sapiens MEGF10 and R.norvegicus Megf10.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 7 species)
Actinopterygii - bony fishes (3 transcripts, 2 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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