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HomoloGene:20396. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   APLP2,  H.sapiens
amyloid beta (A4) precursor-like protein 2
    NP_001633.1
763 aa
   APLP2,  P.troglodytes
amyloid beta (A4) precursor-like protein 2
    XP_001155401.1
761 aa
   APLP2,  M.mulatta
amyloid beta (A4) precursor-like protein 2
    XP_001112057.2
698 aa
   APLP2,  C.lupus
amyloid beta (A4) precursor-like protein 2
    XP_536530.2
763 aa
   APLP2,  B.taurus
amyloid beta (A4) precursor-like protein 2
    XP_002699281.1
767 aa
   Aplp2,  M.musculus
amyloid beta (A4) precursor-like protein 2
    NP_001095925.1
751 aa
   Aplp2,  R.norvegicus
amyloid beta (A4) precursor-like protein 2
    NP_037038.1
765 aa
   APLP2,  G.gallus
amyloid beta (A4) precursor-like protein 2
    NP_001006317.2
753 aa
   aplp2,  D.rerio
amyloid beta (A4) precursor-like protein 2
    NP_001116484.1
764 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The APP family of proteins: similarities and differences.
Walsh DM, et al. Biochem Soc Trans 35, 416-20 (2007).
YWK-II protein/APLP2 in mouse gametes: potential role in fertilization.
Zhuang D, et al. Mol Reprod Dev 73, 61-7 (2006).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
APP_amyloid (pfam10515)
  beta-amyloid precursor protein C-terminus.
APP_Cu_bd (pfam12924)
  Copper-binding of amyloid precursor, CuBD.
APP_E2 (pfam12925)
  E2 domain of amyloid precursor protein.
APP_N (pfam02177)
  Amyloid A4 N-terminal heparin-binding.
APP_N (pfam02177)
  Amyloid A4 N-terminal heparin-binding.
APP_amyloid (pfam10515)
  beta-amyloid precursor protein C-terminus.
APP_E2 (pfam12925)
  E2 domain of amyloid precursor protein.
KU (cl00101)
  BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Aplp2 includes H.sapiens APLP2 and R.norvegicus Aplp2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 15 species)
Actinopterygii - bony fishes (17 transcripts, 11 species)
Amniota - vertebrates (3 transcripts, 1 species)
Aves - birds (3 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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