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HomoloGene:4320. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MC4R,  H.sapiens
melanocortin 4 receptor
    NP_005903.2
332 aa
   MC4R,  P.troglodytes
melanocortin 4 receptor
    NP_001153207.1
332 aa
   MC4R,  M.mulatta
melanocortin 4 receptor
    XP_001088600.1
332 aa
   MC4R,  C.lupus
melanocortin 4 receptor
    NP_001074193.1
332 aa
   MC4R,  B.taurus
melanocortin 4 receptor
    NP_776535.1
332 aa
   Mc4r,  M.musculus
melanocortin 4 receptor
    NP_058673.2
332 aa
   Mc4r,  R.norvegicus
melanocortin 4 receptor
    NP_037231.1
332 aa
   MC4R,  G.gallus
melanocortin 4 receptor
    NP_001026685.1
331 aa
   mc4r,  X.tropicalis
melanocortin 4 receptor
    XP_004915370.1
334 aa
   mc4r,  D.rerio
melanocortin 4 receptor
    NP_775385.1
326 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Obesity, autosomal dominant.



Publications
Articles associated with genes and sequences of this homology group.

MC4R rs489693: a clinical risk factor for second generation antipsychotic-related weight gain?
Czerwensky F, et al. Int J Neuropsychopharmacol 16, 2103-9 (2013).
Molecular genetic aspects of weight regulation.
Hebebrand J, et al. Dtsch Arztebl Int 110, 338-44 (2013).
Melanocortin-4 receptor mutations paradoxically reduce preference for palatable foods.
Panaro BL & Cone RD. Proc Natl Acad Sci U S A 110, 7050-5 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mc4r includes H.sapiens MC4R and R.norvegicus Mc4r.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 12 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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