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HomoloGene:31185. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PPM1D,  H.sapiens
protein phosphatase, Mg2+/Mn2+ dependent, 1D
    NP_003611.1
605 aa
   PPM1D,  P.troglodytes
protein phosphatase, Mg2+/Mn2+ dependent, 1D
    NP_001233479.1
605 aa
   PPM1D,  M.mulatta
protein phosphatase, Mg2+/Mn2+ dependent, 1D
    XP_001110891.1
605 aa
   PPM1D,  C.lupus
protein phosphatase, Mg2+/Mn2+ dependent, 1D
    XP_852759.2
605 aa
   PPM1D,  B.taurus
protein phosphatase, Mg2+/Mn2+ dependent, 1D
    NP_001178373.1
605 aa
   Ppm1d,  M.musculus
protein phosphatase 1D magnesium-dependent, delta isoform
    NP_058606.3
598 aa
   Ppm1d,  R.norvegicus
protein phosphatase, Mg2+/Mn2+ dependent, 1D
    NP_001099295.2
598 aa
   PPM1D,  G.gallus
protein phosphatase, Mg2+/Mn2+ dependent, 1D
    XP_415890.3
441 aa
   ppm1d,  X.tropicalis
protein phosphatase, Mg2+/Mn2+ dependent, 1D
    XP_002933883.2
551 aa
   ppm1db,  D.rerio
protein phosphatase 1D magnesium-dependent, delta isoform b
    NP_001007341.1
534 aa
   ppm1da,  D.rerio
protein phosphatase 1D magnesium-dependent, delta isoform a
    NP_957384.2
535 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Breast cancer.



Publications
Articles associated with genes and sequences of this homology group.

Expression and significance of the Wip1 proto-oncogene in colorectal cancer.
Li ZT, et al. Asian Pac J Cancer Prev 14, 1975-9 (2013).
Regulation of the Wip1 phosphatase and its effects on the stress response.
Lowe J, et al. Front Biosci (Landmark Ed) 17, 1480-98 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PP2C (pfam00481)
  Protein phosphatase 2C.
PP2Cc (cl00120)
  Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ppm1d includes H.sapiens PPM1D and R.norvegicus Ppm1d.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 12 species)
Actinopterygii - bony fishes (7 transcripts, 4 species)
Ascidiacea - tunicates (5 transcripts, 3 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 6 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (3 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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