Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:9160. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SAMHD1,  H.sapiens
SAM domain and HD domain 1
    NP_056289.2
626 aa
   SAMHD1,  P.troglodytes
SAM domain and HD domain 1
    XP_514624.3
610 aa
   SAMHD1,  M.mulatta
SAM domain and HD domain 1
    XP_001097562.2
602 aa
   SAMHD1,  C.lupus
SAM domain and HD domain 1
    XP_542986.3
627 aa
   SAMHD1,  B.taurus
SAM domain and HD domain 1
    NP_001069329.1
589 aa
   Samhd1,  M.musculus
SAM domain and HD domain, 1
    NP_061339.3
658 aa
   Samhd1,  R.norvegicus
SAM domain and HD domain, 1
    NP_001178672.1
620 aa
   SAMHD1,  G.gallus
SAM domain and HD domain 1
    NP_001026016.1
614 aa
   LOC100498574,  X.tropicalis
SAM domain and HD domain-containing protein 1-like
    XP_002932931.2
630 aa
   samhd1,  D.rerio
SAM domain and HD domain 1
    NP_001153405.1
622 aa
   AT5G40270,  A.thaliana
AT5G40270
    NP_568580.1
473 aa
   AT5G40290,  A.thaliana
AT5G40290
    NP_198845.1
448 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Aicardi-Goutieres syndrome 5.



Publications
Articles associated with genes and sequences of this homology group.

Mechanism of allosteric activation of SAMHD1 by dGTP.
Ji X, et al. Nat Struct Mol Biol 20, 1304-9 (2013).
GTP is the primary activator of the anti-HIV restriction factor SAMHD1.
Amie SM, et al. J Biol Chem 288, 25001-6 (2013).
SAMHD1-dependent retroviral control and escape in mice.
Rehwinkel J, et al. EMBO J 32, 2454-62 (2013).
Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells.
Hollenbaugh JA, et al. PLoS Pathog 9, e1003481 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SAM_superfamily (cl15755)
  SAM (Sterile alpha motif ).
SAM_superfamily (cl15755)
  SAM (Sterile alpha motif ).
HDc (cl17215)
  Metal dependent phosphohydrolases with conserved 'HD' motif.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Samhd1 includes H.sapiens SAMHD1 and R.norvegicus Samhd1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (16 transcripts, 7 species)
Mammalia - mammals (12 transcripts, 9 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (29 transcripts, 21 species)
Liliopsida - monocots (9 transcripts, 9 species)
Coniferopsida - conifers (2 transcripts, 1 species)
Bryopsida - mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

 

 

 

Write to the Help Desk