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HomoloGene:5055. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SOX10,  H.sapiens
SRY (sex determining region Y)-box 10
    NP_008872.1
466 aa
   SOX10,  P.troglodytes
SRY (sex determining region Y)-box 10
    XP_525590.4
713 aa
   SOX10,  M.mulatta
SRY (sex determining region Y)-box 10
    XP_002798445.1
467 aa
   SOX10,  C.lupus
SRY (sex determining region Y)-box 10
    XP_538379.3
468 aa
   SOX10,  B.taurus
SRY (sex determining region Y)-box 10
    NP_001180176.1
469 aa
   Sox10,  M.musculus
SRY (sex determining region Y)-box 10
    NP_035567.1
466 aa
   Sox10,  R.norvegicus
SRY (sex determining region Y)-box 10
    NP_062066.1
466 aa
   SOX10,  G.gallus
SRY (sex determining region Y)-box 10
    NP_990123.1
461 aa
   sox10,  X.tropicalis
SRY (sex determining region Y)-box 10
    NP_001093691.1
436 aa
   sox10,  D.rerio
SRY-box containing gene 10
    NP_571950.1
485 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Waardenburg-Shah syndrome.
Yemenite deaf-blind hypopigmentation syndrome.
PCWH.



Publications
Articles associated with genes and sequences of this homology group.

Sox10 nuclear immunostaining lacks diagnostic utility for CNS granular cell tumors.
Wisell J & Kleinschmidt-DeMasters BK. J Neuropathol Exp Neurol 73, 98-100 (2014).
Value of SOX10 immunostaining in tumor diagnosis.
Ordóñez NG. Adv Anat Pathol 20, 275-83 (2013).
Spectrum of temporal bone abnormalities in patients with Waardenburg syndrome and SOX10 mutations.
Elmaleh-Bergès M, et al. AJNR Am J Neuroradiol 34, 1257-63 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Sox_N (pfam12444)
  Sox developmental protein N terminal.
Sox_N (pfam12444)
  Sox developmental protein N terminal.
HMG-box (cl00082)
  High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sox10 includes H.sapiens SOX10 and R.norvegicus Sox10.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 8 species)
Actinopterygii - bony fishes (5 transcripts, 5 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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